ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galactose-1-phosphate uridylyltransferase

Intramolecular
Cysteine 75 and cysteine 130
Cysteine 130 and cysteine 187
A redox-regulated disulphide may form within Galactose-1-phosphate uridylyltransferase between cysteines 75 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6gqd
Structure name
structure of human galactose-1-phosphate uridylyltransferase (galt), with crystallization epitope mutations a21y:a22t:t23p:r25l
Structure deposition date
2018-06-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
68
Peptide accession
P07902
Residue number A
75
Residue number B
130
Peptide name
Galactose-1-phosphate uridylyltransferase

Ligandability

Cysteine 75 of Galactose-1-phosphate uridylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Galactose-1-phosphate uridylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactose-1-phosphate uridylyltransferase between cysteines 130 and 187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5in3
Structure name
crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase
Structure deposition date
2016-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
P07902
Residue number A
130
Residue number B
187
Peptide name
Galactose-1-phosphate uridylyltransferase

Ligandability

Cysteine 130 of Galactose-1-phosphate uridylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Galactose-1-phosphate uridylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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