ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytochrome b-c1 complex subunit 6, mitochondrial

Intermolecular
Cysteine 67 and cysteine 219 of Cytochrome c1, heme protein, mitochondrial L
Intramolecular
Cysteine 37 and cysteine 81 L
Cysteine 53 and cysteine 67 L
Cysteine 43 and cysteine 81 L
Cysteine 37 and cysteine 43 L
A redox-regulated disulphide may form between cysteine 67 of Cytochrome b-c1 complex subunit 6, mitochondrial and cysteine 219 of Cytochrome c1, heme protein, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5xte
Structure name
cryo-em structure of human respiratory complex iii (cytochrome bc1 complex)
Structure deposition date
2017-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
58
Peptide A name
Cytochrome b-c1 complex subunit 6, mitochondrial
Peptide B name
Cytochrome c1, heme protein, mitochondrial
Peptide A accession
P07919
Peptide B accession
P08574
Peptide A residue number
67
Peptide B residue number
219

Ligandability

Cysteine 67 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Cytochrome c1, heme protein, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 6, mitochondrial between cysteines 37 and 81 (24 and 68 respectively in this structure).

Details

Redox score ?
83
PDB code
1sqv
Structure name
crystal structure analysis of bovine bc1 with uhdbt
Structure deposition date
2004-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00126
Residue number A
37
Residue number B
81
Peptide name
Cytochrome b-c1 complex subunit 6, mitochondrial

Ligandability

Cysteine 37 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 6, mitochondrial between cysteines 53 and 67 (40 and 54 respectively in this structure).

Details

Redox score ?
79
PDB code
1ntz
Structure name
crystal structure of mitochondrial cytochrome bc1 complex bound with ubiquinone
Structure deposition date
2003-01-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
22
Peptide accession
P00126
Residue number A
53
Residue number B
67
Peptide name
Cytochrome b-c1 complex subunit 6, mitochondrial

Ligandability

Cysteine 53 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 6, mitochondrial between cysteines 43 and 81 (30 and 68 respectively in this structure).

Details

Redox score ?
68
PDB code
5klv
Structure name
structure of bos taurus cytochrome bc1 with fenamidone inhibited
Structure deposition date
2016-06-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
nan
Peptide accession
P00126
Residue number A
43
Residue number B
81
Peptide name
Cytochrome b-c1 complex subunit 6, mitochondrial

Ligandability

Cysteine 43 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 6, mitochondrial between cysteines 37 and 43 (24 and 30 respectively in this structure).

Details

Redox score ?
62
PDB code
1l0l
Structure name
structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
Structure deposition date
2002-02-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
nan
Peptide accession
P00126
Residue number A
37
Residue number B
43
Peptide name
Cytochrome b-c1 complex subunit 6, mitochondrial

Ligandability

Cysteine 37 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Cytochrome b-c1 complex subunit 6, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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