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a tool for identifying drug-targetable redox-active disulphides

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Proto-oncogene tyrosine-protein kinase receptor Ret

Intramolecular
Cysteine 449 and cysteine 478
Cysteine 157 and cysteine 197
Cysteine 515 and cysteine 531
Cysteine 137 and cysteine 142
Cysteine 166 and cysteine 243
Cysteine 519 and cysteine 541
Cysteine 426 and cysteine 430
Cysteine 565 and cysteine 581
Cysteine 528 and cysteine 558
Cysteine 570 and cysteine 585
More...
Cysteine 609 and cysteine 620
Cysteine 611 and cysteine 618
Cysteine 541 and cysteine 558
Cysteine 528 and cysteine 541
Cysteine 519 and cysteine 558
Cysteine 519 and cysteine 528
Cysteine 618 and cysteine 620
Cysteine 531 and cysteine 541
Cysteine 581 and cysteine 585
Cysteine 611 and cysteine 620
Cysteine 570 and cysteine 581
Cysteine 515 and cysteine 541
Cysteine 609 and cysteine 611
Cysteine 519 and cysteine 565
Cysteine 565 and cysteine 585
Cysteine 609 and cysteine 618
Cysteine 565 and cysteine 570
Cysteine 519 and cysteine 531
Cysteine 531 and cysteine 558
Cysteine 528 and cysteine 531
Cysteine 515 and cysteine 519
Cysteine 565 and cysteine 611
Cysteine 581 and cysteine 611
Cysteine 541 and cysteine 565
Cysteine 515 and cysteine 558
Cysteine 558 and cysteine 565
Cysteine 581 and cysteine 618
Cysteine 519 and cysteine 581
A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 449 and 478.

Details

Redox score ?
91
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
449
Residue number B
478
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 449 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 157 and 197.

Details

Redox score ?
88
PDB code
2x2u
Structure name
first two cadherin-like domains from human ret
Structure deposition date
2010-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
157
Residue number B
197
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 157 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 515 and 531.

Details

Redox score ?
85
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
515
Residue number B
531
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 515 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 531 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 137 and 142.

Details

Redox score ?
85
PDB code
2x2u
Structure name
first two cadherin-like domains from human ret
Structure deposition date
2010-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
137
Residue number B
142
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 137 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 166 and 243.

Details

Redox score ?
84
PDB code
2x2u
Structure name
first two cadherin-like domains from human ret
Structure deposition date
2010-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
166
Residue number B
243
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 166 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 541.

Details

Redox score ?
83
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
541
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 426 and 430.

Details

Redox score ?
83
PDB code
6gl7
Structure name
neurturin-gfra2-ret extracellular complex
Structure deposition date
2018-05-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
10
Peptide accession
P07949
Residue number A
426
Residue number B
430
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 426 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 430 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 565 and 581.

Details

Redox score ?
82
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
565
Residue number B
581
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 528 and 558.

Details

Redox score ?
82
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
528
Residue number B
558
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 528 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 570 and 585.

Details

Redox score ?
82
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
570
Residue number B
585
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 570 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 585 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 609 and 620.

Details

Redox score ?
82
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
609
Residue number B
620
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 609 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 611 and 618.

Details

Redox score ?
80
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
611
Residue number B
618
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 611 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 541 and 558.

Details

Redox score ?
69
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
541
Residue number B
558
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 528 and 541.

Details

Redox score ?
67
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
528
Residue number B
541
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 528 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 558.

Details

Redox score ?
63
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
558
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 528.

Details

Redox score ?
61
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
528
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 528 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 618 and 620. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
618
Residue number B
620
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 618 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 531 and 541. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
531
Residue number B
541
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 531 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 581 and 585. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
581
Residue number B
585
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 585 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 611 and 620. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
611
Residue number B
620
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 611 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 570 and 581. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
570
Residue number B
581
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 570 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 515 and 541. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
515
Residue number B
541
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 515 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 609 and 611. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
609
Residue number B
611
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 609 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 611 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 565. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6q2r
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Structure deposition date
2019-08-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
565
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 565 and 585. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
565
Residue number B
585
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 585 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 609 and 618. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6q2o
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
609
Residue number B
618
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 609 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 565 and 570. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
565
Residue number B
570
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 570 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 531. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
531
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 531 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 531 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
531
Residue number B
558
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 531 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 528 and 531. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
528
Residue number B
531
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 528 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 531 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 515 and 519. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
515
Residue number B
519
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 515 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 565 and 611. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
565
Residue number B
611
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 611 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 581 and 611. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6q2o
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
581
Residue number B
611
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 611 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 541 and 565. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6q2j
Structure name
cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
541
Residue number B
565
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 541 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 515 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
515
Residue number B
558
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 515 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 558 and 565. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
558
Residue number B
565
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 558 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 581 and 618. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6q2o
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
581
Residue number B
618
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 618 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proto-oncogene tyrosine-protein kinase receptor Ret between cysteines 519 and 581. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07949
Residue number A
519
Residue number B
581
Peptide name
Proto-oncogene tyrosine-protein kinase receptor Ret

Ligandability

Cysteine 519 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 581 of Proto-oncogene tyrosine-protein kinase receptor Ret

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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