ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fumarate hydratase, mitochondrial

Intramolecular
Cysteine 377 and cysteine 434
A redox-regulated disulphide may form within Fumarate hydratase, mitochondrial between cysteines 377 and 434.

Details

Redox score ?
69
PDB code
6ebt
Structure name
crystal structure of recombinant mutant n107t of human fumarase
Structure deposition date
2018-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
8
% buried
85
Peptide accession
P07954
Residue number A
377
Residue number B
434
Peptide name
Fumarate hydratase, mitochondrial

Ligandability

Cysteine 377 of Fumarate hydratase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Fumarate hydratase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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