ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

DNA excision repair protein ERCC-1

Intramolecular
Cysteine 189 and cysteine 194
Cysteine 137 and cysteine 194
A redox-regulated disulphide may form within DNA excision repair protein ERCC-1 between cysteines 189 and 194.

Details

Redox score ?
85
PDB code
2a1i
Structure name
crystal structure of the central domain of human ercc1
Structure deposition date
2005-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
50
Peptide accession
P07992
Residue number A
189
Residue number B
194
Peptide name
DNA excision repair protein ERCC-1

Ligandability

Cysteine 189 of DNA excision repair protein ERCC-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of DNA excision repair protein ERCC-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA excision repair protein ERCC-1 between cysteines 137 and 194. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2a1i
Structure name
crystal structure of the central domain of human ercc1
Structure deposition date
2005-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
56
Peptide accession
P07992
Residue number A
137
Residue number B
194
Peptide name
DNA excision repair protein ERCC-1

Ligandability

Cysteine 137 of DNA excision repair protein ERCC-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of DNA excision repair protein ERCC-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: