ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho-related GTP-binding protein RhoC

Intramolecular
Cysteine 16 and cysteine 83
Cysteine 83 and cysteine 159
Cysteine 16 and cysteine 159
A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoC between cysteines 16 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2gco
Structure name
crystal structure of the human rhoc-gppnhp complex
Structure deposition date
2006-03-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
P08134
Residue number A
16
Residue number B
83
Peptide name
Rho-related GTP-binding protein RhoC

Ligandability

Cysteine 16 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoC between cysteines 83 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2gco
Structure name
crystal structure of the human rhoc-gppnhp complex
Structure deposition date
2006-03-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P08134
Residue number A
83
Residue number B
159
Peptide name
Rho-related GTP-binding protein RhoC

Ligandability

Cysteine 83 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoC between cysteines 16 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
2gco
Structure name
crystal structure of the human rhoc-gppnhp complex
Structure deposition date
2006-03-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
100
Peptide accession
P08134
Residue number A
16
Residue number B
159
Peptide name
Rho-related GTP-binding protein RhoC

Ligandability

Cysteine 16 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Rho-related GTP-binding protein RhoC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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