ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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4F2 cell-surface antigen heavy chain

Intermolecular
Cysteine 210 and cysteine 158 of Cystine/glutamate transporter
Cysteine 164 of Large neutral amino acids transporter small subunit 1 and cysteine 210
Cysteine 210 and cysteine 154 of Large neutral amino acids transporter small subunit 2
A redox-regulated disulphide may form between cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 158 of Cystine/glutamate transporter (211 and 158 respectively in this structure).

Details

Redox score ?
88
PDB code
7epz
Structure name
overall structure of erastin-bound xct-4f2hc complex
Structure deposition date
2021-04-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide A name
4F2 cell-surface antigen heavy chain
Peptide B name
Cystine/glutamate transporter
Peptide A accession
J3KPF3
Peptide B accession
Q9UPY5
Peptide A residue number
210
Peptide B residue number
158

Ligandability

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Cystine/glutamate transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 164 of Large neutral amino acids transporter small subunit 1 and cysteine 210 of 4F2 cell-surface antigen heavy chain.

Details

Redox score ?
87
PDB code
6jmq
Structure name
lat1-cd98hc complex bound to mem-108 fab
Structure deposition date
2019-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Large neutral amino acids transporter small subunit 1
Peptide B name
4F2 cell-surface antigen heavy chain
Peptide A accession
Q01650
Peptide B accession
P08195
Peptide A residue number
164
Peptide B residue number
210

Ligandability

Cysteine 164 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 210 of 4F2 cell-surface antigen heavy chain and cysteine 154 of Large neutral amino acids transporter small subunit 2 (211 and 154 respectively in this structure).

Details

Redox score ?
87
PDB code
7cmi
Structure name
the lat2-4f2hc complex in complex with leucine
Structure deposition date
2020-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
4F2 cell-surface antigen heavy chain
Peptide B name
Large neutral amino acids transporter small subunit 2
Peptide A accession
J3KPF3
Peptide B accession
Q9UHI5
Peptide A residue number
210
Peptide B residue number
154

Ligandability

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Large neutral amino acids transporter small subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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