ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Chymotrypsin-like elastase family member 2A

Intramolecular
Cysteine 155 and cysteine 222
Cysteine 186 and cysteine 202
Cysteine 58 and cysteine 74
Cysteine 212 and cysteine 243
A redox-regulated disulphide may form within Chymotrypsin-like elastase family member 2A between cysteines 155 and 222 (136 and 201 respectively in this structure).

Details

Redox score ?
84
PDB code
1bru
Structure name
structure of porcine pancreatic elastase complexed with the elastase inhibitor gr143783
Structure deposition date
1998-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08419
Residue number A
155
Residue number B
222
Peptide name
Chymotrypsin-like elastase family member 2A

Ligandability

Cysteine 155 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chymotrypsin-like elastase family member 2A between cysteines 186 and 202 (168 and 182 respectively in this structure).

Details

Redox score ?
80
PDB code
1bru
Structure name
structure of porcine pancreatic elastase complexed with the elastase inhibitor gr143783
Structure deposition date
1998-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08419
Residue number A
186
Residue number B
202
Peptide name
Chymotrypsin-like elastase family member 2A

Ligandability

Cysteine 186 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chymotrypsin-like elastase family member 2A between cysteines 58 and 74 (42 and 58 respectively in this structure).

Details

Redox score ?
80
PDB code
1bru
Structure name
structure of porcine pancreatic elastase complexed with the elastase inhibitor gr143783
Structure deposition date
1998-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08419
Residue number A
58
Residue number B
74
Peptide name
Chymotrypsin-like elastase family member 2A

Ligandability

Cysteine 58 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chymotrypsin-like elastase family member 2A between cysteines 212 and 243 (191 and 220 respectively in this structure).

Details

Redox score ?
79
PDB code
1bru
Structure name
structure of porcine pancreatic elastase complexed with the elastase inhibitor gr143783
Structure deposition date
1998-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08419
Residue number A
212
Residue number B
243
Peptide name
Chymotrypsin-like elastase family member 2A

Ligandability

Cysteine 212 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of Chymotrypsin-like elastase family member 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: