ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Mineralocorticoid receptor

Intermolecular
Cysteine 645 and cysteine 645
Cysteine 639 and cysteine 639
Cysteine 655 and cysteine 655
Intramolecular
Cysteine 639 and cysteine 645
Cysteine 620 and cysteine 623
Cysteine 639 and cysteine 658
Cysteine 639 and cysteine 655
Cysteine 645 and cysteine 655
Cysteine 655 and cysteine 658
Cysteine 645 and cysteine 658
More...
Cysteine 603 and cysteine 606
Cysteine 603 and cysteine 620
Cysteine 603 and cysteine 623
Cysteine 606 and cysteine 620
Cysteine 606 and cysteine 623
Cysteine 623 and cysteine 663
Cysteine 603 and cysteine 663
Cysteine 620 and cysteine 663
Cysteine 606 and cysteine 663
A redox-regulated disulphide may form between two units of Mineralocorticoid receptor at cysteines 645 and 645.

Details

Redox score ?
61
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
40
Peptide A name
Mineralocorticoid receptor
Peptide B name
Mineralocorticoid receptor
Peptide A accession
P08235
Peptide B accession
P08235
Peptide A residue number
645
Peptide B residue number
645

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Mineralocorticoid receptor at cysteines 639 and 639. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
29
Peptide A name
Mineralocorticoid receptor
Peptide B name
Mineralocorticoid receptor
Peptide A accession
P08235
Peptide B accession
P08235
Peptide A residue number
639
Peptide B residue number
639

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Mineralocorticoid receptor at cysteines 655 and 655. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
64
Peptide A name
Mineralocorticoid receptor
Peptide B name
Mineralocorticoid receptor
Peptide A accession
P08235
Peptide B accession
P08235
Peptide A residue number
655
Peptide B residue number
655

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 639 and 645.

Details

Redox score ?
85
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
34
Peptide accession
P08235
Residue number A
639
Residue number B
645
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 639 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 645 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 620 and 623.

Details

Redox score ?
84
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
4
% buried
81
Peptide accession
P08235
Residue number A
620
Residue number B
623
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 620 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 623 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 639 and 658.

Details

Redox score ?
80
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
32
Peptide accession
P08235
Residue number A
639
Residue number B
658
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 639 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 658 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 639 and 655.

Details

Redox score ?
80
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
46
Peptide accession
P08235
Residue number A
639
Residue number B
655
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 639 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 655 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 645 and 655.

Details

Redox score ?
78
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
52
Peptide accession
P08235
Residue number A
645
Residue number B
655
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 645 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 655 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 655 and 658.

Details

Redox score ?
74
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
49
Peptide accession
P08235
Residue number A
655
Residue number B
658
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 655 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 658 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 645 and 658.

Details

Redox score ?
72
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
38
Peptide accession
P08235
Residue number A
645
Residue number B
658
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 645 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 658 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 603 and 606.

Details

Redox score ?
69
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
nan
Peptide accession
P08235
Residue number A
603
Residue number B
606
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 603 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 606 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 603 and 620.

Details

Redox score ?
68
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
13
% buried
nan
Peptide accession
P08235
Residue number A
603
Residue number B
620
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 603 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 603 and 623.

Details

Redox score ?
67
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
13
% buried
72
Peptide accession
P08235
Residue number A
603
Residue number B
623
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 603 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 623 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 606 and 620.

Details

Redox score ?
65
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
13
% buried
nan
Peptide accession
P08235
Residue number A
606
Residue number B
620
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 606 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 606 and 623.

Details

Redox score ?
64
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
72
Peptide accession
P08235
Residue number A
606
Residue number B
623
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 606 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 623 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 623 and 663. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
84
Peptide accession
P08235
Residue number A
623
Residue number B
663
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 623 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 663 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 603 and 663. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
nan
Peptide accession
P08235
Residue number A
603
Residue number B
663
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 603 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 663 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 620 and 663. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
nan
Peptide accession
P08235
Residue number A
620
Residue number B
663
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 620 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 663 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mineralocorticoid receptor between cysteines 606 and 663. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4tnt
Structure name
structure of the human mineralocorticoid receptor in complex with dna
Structure deposition date
2014-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
68
Peptide accession
P08235
Residue number A
606
Residue number B
663
Peptide name
Mineralocorticoid receptor

Ligandability

Cysteine 606 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 663 of Mineralocorticoid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: