ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Signal recognition particle receptor subunit alpha

Intermolecular
Cysteine 621 and cysteine 621
Intramolecular
Cysteine 17 and cysteine 25 L
A redox-regulated disulphide may form between two units of Signal recognition particle receptor subunit alpha at cysteines 621 and 621.

Details

Redox score ?
80
PDB code
6y32
Structure name
structure of the gtpase heterodimer of human srp54 and sralpha
Structure deposition date
2020-02-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
Signal recognition particle receptor subunit alpha
Peptide B name
Signal recognition particle receptor subunit alpha
Peptide A accession
P08240
Peptide B accession
P08240
Peptide A residue number
621
Peptide B residue number
621

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal recognition particle receptor subunit alpha between cysteines 17 and 25.

Details

Redox score ?
86
PDB code
2fh5
Structure name
the structure of the mammalian srp receptor
Structure deposition date
2005-12-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08240
Residue number A
17
Residue number B
25
Peptide name
Signal recognition particle receptor subunit alpha

Ligandability

Cysteine 17 of Signal recognition particle receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Signal recognition particle receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: