Apolipoprotein(a)
Intramolecular
Cysteine 142 and cysteine 1017
Cysteine 1720 and cysteine 1799
Cysteine 1616 and cysteine 1017
Cysteine 28 and cysteine 105
Cysteine 28 and cysteine 1351
Cysteine 142 and cysteine 105
Cysteine 1168 and cysteine 1245
Cysteine 77 and cysteine 100
Cysteine 1388 and cysteine 1465
Cysteine 1665 and cysteine 1688
More...Cysteine 1103 and cysteine 100
Cysteine 1770 and cysteine 1794
Cysteine 1189 and cysteine 1676
Cysteine 1741 and cysteine 1782
Cysteine 1189 and cysteine 1228
Cysteine 49 and cysteine 88
Cysteine 1409 and cysteine 1114
Cysteine 1189 and cysteine 1114
Cysteine 1103 and cysteine 1012
Cysteine 1189 and cysteine 1688
Cysteine 1189 and cysteine 100
Cysteine 1676 and cysteine 1688
Cysteine 1189 and cysteine 1103
Cysteine 1189 and cysteine 1665
Cysteine 1114 and cysteine 100
Cysteine 49 and cysteine 77
Cysteine 1741 and cysteine 1770
Cysteine 1741 and cysteine 1794
Cysteine 49 and cysteine 100
Cysteine 1782 and cysteine 1794
Cysteine 88 and cysteine 100
Cysteine 1770 and cysteine 1782
Cysteine 1665 and cysteine 1676
Cysteine 77 and cysteine 88
Cysteine 1103 and cysteine 1114
Cysteine 1103 and cysteine 1228
Cysteine 1228 and cysteine 100
Cysteine 1409 and cysteine 1103
Cysteine 1114 and cysteine 1012
Cysteine 1409 and cysteine 1012
4bv5 A 1 A 80
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 142 and 1017 (1 and 80 respectively in this structure).
Details
Redox score ?
94
PDB code
4bv5
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
142
Residue number B
1017
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 142 of Apolipoprotein(a)
Cysteine 1017 of Apolipoprotein(a)
4bvv A 1 A 80
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1720 and 1799 (1 and 80 respectively in this structure).
Details
Redox score ?
88
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1720
Residue number B
1799
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1720 of Apolipoprotein(a)
Cysteine 1799 of Apolipoprotein(a)
3kiv A 1 A 80
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1616 and 1017 (1 and 80 respectively in this structure).
Details
Redox score ?
88
PDB code
3kiv
Structure name
recombinant kringle iv-10/m66 variant of human apolipoprotein(a)
Structure deposition date
1998-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1616
Residue number B
1017
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1616 of Apolipoprotein(a)
Cysteine 1017 of Apolipoprotein(a)
4bvw A 1 A 78
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 28 and 105 (1 and 78 respectively in this structure).
Details
Redox score ?
88
PDB code
4bvw
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
28
Residue number B
105
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 28 of Apolipoprotein(a)
Cysteine 105 of Apolipoprotein(a)
1i71 A 1 A 78
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 28 and 1351 (1 and 78 respectively in this structure).
Details
Redox score ?
85
PDB code
1i71
Structure name
high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding
Structure deposition date
2001-03-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
28
Residue number B
1351
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 28 of Apolipoprotein(a)
Cysteine 1351 of Apolipoprotein(a)
6rx7 C 1 C 78
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 142 and 105 (1 and 78 respectively in this structure).
Details
Redox score ?
85
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
142
Residue number B
105
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 142 of Apolipoprotein(a)
Cysteine 105 of Apolipoprotein(a)
1jfn A 25 A 102
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1168 and 1245 (25 and 102 respectively in this structure).
Details
Redox score ?
84
PDB code
1jfn
Structure name
solution structure of human apolipoprotein(a) kringle iv type 6
Structure deposition date
2001-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1168
Residue number B
1245
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1168 of Apolipoprotein(a)
Cysteine 1245 of Apolipoprotein(a)
6rx7 A 50 A 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 77 and 100 (50 and 73 respectively in this structure).
Details
Redox score ?
83
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
77
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 77 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
2feb A 18 A 95
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1388 and 1465 (18 and 95 respectively in this structure).
Details
Redox score ?
83
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1388
Residue number B
1465
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1388 of Apolipoprotein(a)
Cysteine 1465 of Apolipoprotein(a)
3kiv A 51 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1665 and 1688 (51 and 75 respectively in this structure).
Details
Redox score ?
83
PDB code
3kiv
Structure name
recombinant kringle iv-10/m66 variant of human apolipoprotein(a)
Structure deposition date
1998-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1665
Residue number B
1688
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1665 of Apolipoprotein(a)
Cysteine 1688 of Apolipoprotein(a)
1i71 A 50 A 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1103 and 100 (50 and 73 respectively in this structure).
Details
Redox score ?
83
PDB code
1i71
Structure name
high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding
Structure deposition date
2001-03-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1103
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1103 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
4bvv A 51 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1770 and 1794 (51 and 75 respectively in this structure).
Details
Redox score ?
82
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1770
Residue number B
1794
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1770 of Apolipoprotein(a)
Cysteine 1794 of Apolipoprotein(a)
4bvc A 22 A 63
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1676 (22 and 63 respectively in this structure).
Details
Redox score ?
82
PDB code
4bvc
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1676
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1676 of Apolipoprotein(a)
4bvv A 22 A 63
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1741 and 1782 (22 and 63 respectively in this structure).
Details
Redox score ?
82
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1741
Residue number B
1782
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1741 of Apolipoprotein(a)
Cysteine 1782 of Apolipoprotein(a)
1jfn A 46 A 85
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1228 (46 and 85 respectively in this structure).
Details
Redox score ?
82
PDB code
1jfn
Structure name
solution structure of human apolipoprotein(a) kringle iv type 6
Structure deposition date
2001-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1228
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1228 of Apolipoprotein(a)
6rx7 C 22 C 61
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 49 and 88 (22 and 61 respectively in this structure).
Details
Redox score ?
81
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
49
Residue number B
88
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 49 of Apolipoprotein(a)
Cysteine 88 of Apolipoprotein(a)
2feb A 39 A 78
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1409 and 1114 (39 and 78 respectively in this structure).
Details
Redox score ?
81
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1409
Residue number B
1114
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1409 of Apolipoprotein(a)
Cysteine 1114 of Apolipoprotein(a)
4bvw A 22 A 61
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1114 (22 and 61 respectively in this structure).
Details
Redox score ?
81
PDB code
4bvw
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1114
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1114 of Apolipoprotein(a)
2feb A 67 A 90
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1103 and 1012 (67 and 90 respectively in this structure).
Details
Redox score ?
80
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1103
Residue number B
1012
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1103 of Apolipoprotein(a)
Cysteine 1012 of Apolipoprotein(a)
1kiv A 22 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1688 (22 and 75 respectively in this structure).
Details
Redox score ?
74
PDB code
1kiv
Structure name
recombinant kringle iv-10/m66 variant of human apolipoprotein(a)
Structure deposition date
1998-08-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1688
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1688 of Apolipoprotein(a)
1i71 A 22 A 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 100 (22 and 73 respectively in this structure).
Details
Redox score ?
74
PDB code
1i71
Structure name
high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding
Structure deposition date
2001-03-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
4bv7 A 63 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1676 and 1688 (63 and 75 respectively in this structure).
Details
Redox score ?
72
PDB code
4bv7
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1676
Residue number B
1688
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1676 of Apolipoprotein(a)
Cysteine 1688 of Apolipoprotein(a)
4bvw A 22 A 50
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1103 (22 and 50 respectively in this structure).
Details
Redox score ?
72
PDB code
4bvw
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1103
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1103 of Apolipoprotein(a)
4bv5 A 22 A 51
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1189 and 1665 (22 and 51 respectively in this structure).
Details
Redox score ?
71
PDB code
4bv5
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1189
Residue number B
1665
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1189 of Apolipoprotein(a)
Cysteine 1665 of Apolipoprotein(a)
4bvw A 61 A 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1114 and 100 (61 and 73 respectively in this structure).
Details
Redox score ?
71
PDB code
4bvw
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1114
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1114 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
6rx7 B 22 B 50
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 49 and 77 (22 and 50 respectively in this structure).
Details
Redox score ?
71
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
49
Residue number B
77
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 49 of Apolipoprotein(a)
Cysteine 77 of Apolipoprotein(a)
4bvv A 22 A 51
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1741 and 1770 (22 and 51 respectively in this structure).
Details
Redox score ?
71
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1741
Residue number B
1770
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1741 of Apolipoprotein(a)
Cysteine 1770 of Apolipoprotein(a)
4bvv A 22 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1741 and 1794 (22 and 75 respectively in this structure).
Details
Redox score ?
70
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1741
Residue number B
1794
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1741 of Apolipoprotein(a)
Cysteine 1794 of Apolipoprotein(a)
6rx7 C 22 C 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 49 and 100 (22 and 73 respectively in this structure).
Details
Redox score ?
70
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
49
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 49 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
4bvv A 63 A 75
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1782 and 1794 (63 and 75 respectively in this structure).
Details
Redox score ?
70
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1782
Residue number B
1794
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1782 of Apolipoprotein(a)
Cysteine 1794 of Apolipoprotein(a)
6rx7 C 61 C 73
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 88 and 100 (61 and 73 respectively in this structure).
Details
Redox score ?
69
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
88
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 88 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
4bvv A 51 A 63
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1770 and 1782 (51 and 63 respectively in this structure).
Details
Redox score ?
65
PDB code
4bvv
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1770
Residue number B
1782
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1770 of Apolipoprotein(a)
Cysteine 1782 of Apolipoprotein(a)
4bv5 B 51 B 63
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1665 and 1676 (51 and 63 respectively in this structure).
Details
Redox score ?
65
PDB code
4bv5
Structure name
identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv
Structure deposition date
2013-06-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1665
Residue number B
1676
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1665 of Apolipoprotein(a)
Cysteine 1676 of Apolipoprotein(a)
6rx7 C 50 C 61
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 77 and 88 (50 and 61 respectively in this structure).
Details
Redox score ?
64
PDB code
6rx7
Structure name
structure of the kiv type 2 (kiv-2) domain of lipoprotein (a)
Structure deposition date
2019-06-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
77
Residue number B
88
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 77 of Apolipoprotein(a)
Cysteine 88 of Apolipoprotein(a)
1i71 A 50 A 61
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1103 and 1114 (50 and 61 respectively in this structure).
Details
Redox score ?
64
PDB code
1i71
Structure name
high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding
Structure deposition date
2001-03-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1103
Residue number B
1114
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1103 of Apolipoprotein(a)
Cysteine 1114 of Apolipoprotein(a)
1jfn A 74 A 85
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1103 and 1228 (74 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
1jfn
Structure name
solution structure of human apolipoprotein(a) kringle iv type 6
Structure deposition date
2001-06-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1103
Residue number B
1228
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1103 of Apolipoprotein(a)
Cysteine 1228 of Apolipoprotein(a)
1jfn A 85 A 97
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1228 and 100 (85 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1jfn
Structure name
solution structure of human apolipoprotein(a) kringle iv type 6
Structure deposition date
2001-06-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1228
Residue number B
100
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1228 of Apolipoprotein(a)
Cysteine 100 of Apolipoprotein(a)
2feb A 39 A 67
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1409 and 1103 (39 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1409
Residue number B
1103
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1409 of Apolipoprotein(a)
Cysteine 1103 of Apolipoprotein(a)
2feb A 78 A 90
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1114 and 1012 (78 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1114
Residue number B
1012
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1114 of Apolipoprotein(a)
Cysteine 1012 of Apolipoprotein(a)
2feb A 39 A 90
A redox-regulated disulphide may form within Apolipoprotein(a) between cysteines 1409 and 1012 (39 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2feb
Structure name
nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a)
Structure deposition date
2005-12-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08519
Residue number A
1409
Residue number B
1012
Peptide name
Apolipoprotein(a)
Ligandability
Cysteine 1409 of Apolipoprotein(a)
Cysteine 1012 of Apolipoprotein(a)
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