ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Monocyte differentiation antigen CD14

Intramolecular
Cysteine 23 and cysteine 32
Cysteine 34 and cysteine 51
Cysteine 241 and cysteine 272
Cysteine 187 and cysteine 217
Cysteine 23 and cysteine 47
Cysteine 23 and cysteine 30
Cysteine 36 and cysteine 51
Cysteine 34 and cysteine 36
A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 23 and 32 (8 and 17 respectively in this structure).

Details

Redox score ?
86
PDB code
1wwl
Structure name
crystal structure of cd14
Structure deposition date
2005-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10810
Residue number A
23
Residue number B
32
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 23 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 34 and 51.

Details

Redox score ?
85
PDB code
4glp
Structure name
the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket
Structure deposition date
2012-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08571
Residue number A
34
Residue number B
51
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 34 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 241 and 272.

Details

Redox score ?
85
PDB code
4glp
Structure name
the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket
Structure deposition date
2012-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08571
Residue number A
241
Residue number B
272
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 241 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 187 and 217.

Details

Redox score ?
85
PDB code
4glp
Structure name
the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket
Structure deposition date
2012-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08571
Residue number A
187
Residue number B
217
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 187 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 23 and 47 (8 and 32 respectively in this structure).

Details

Redox score ?
77
PDB code
1wwl
Structure name
crystal structure of cd14
Structure deposition date
2005-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10810
Residue number A
23
Residue number B
47
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 23 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 23 and 30 (8 and 15 respectively in this structure).

Details

Redox score ?
70
PDB code
1wwl
Structure name
crystal structure of cd14
Structure deposition date
2005-01-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10810
Residue number A
23
Residue number B
30
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 23 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 30 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 36 and 51.

Details

Redox score ?
66
PDB code
4glp
Structure name
the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket
Structure deposition date
2012-08-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
nan
Peptide accession
P08571
Residue number A
36
Residue number B
51
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 36 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocyte differentiation antigen CD14 between cysteines 34 and 36. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4glp
Structure name
the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket
Structure deposition date
2012-08-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
nan
Peptide accession
P08571
Residue number A
34
Residue number B
36
Peptide name
Monocyte differentiation antigen CD14

Ligandability

Cysteine 34 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Monocyte differentiation antigen CD14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: