ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-1 adrenergic receptor

Intramolecular
Cysteine 209 and cysteine 215
Cysteine 141 and cysteine 24
A redox-regulated disulphide may form within Beta-1 adrenergic receptor between cysteines 209 and 215 (13 and 19 respectively in this structure).

Details

Redox score ?
88
PDB code
2lsq
Structure name
analog of the fragment 197-221 of beta-1 adrenoreceptor
Structure deposition date
2012-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08588
Residue number A
209
Residue number B
215
Peptide name
Beta-1 adrenergic receptor

Ligandability

Cysteine 209 of Beta-1 adrenergic receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Beta-1 adrenergic receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1 adrenergic receptor between cysteines 141 and 24 (2 and 24 respectively in this structure).

Details

Redox score ?
nan
PDB code
2lsq
Structure name
analog of the fragment 197-221 of beta-1 adrenoreceptor
Structure deposition date
2012-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
27
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08588
Residue number A
141
Residue number B
24
Peptide name
Beta-1 adrenergic receptor

Ligandability

Cysteine 141 of Beta-1 adrenergic receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Beta-1 adrenergic receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 in protein B could not be asigned to a Uniprot residue.
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