a tool for identifying drug-targetable redox-active disulphides

Interleukin-3

Intramolecular

Cysteine 35 and cysteine 103

A redox-regulated disulphide may form within Interleukin-3 between cysteines 35 and 103 (16 and 84 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

cytokine-receptor complex

Structure deposition date

2017-02-21

Thiol separation (Å)

3

Half-sphere exposure sum ?

49

Minimum pK_a ?

9

% buried

25

Peptide accession

Residue number A

35

Residue number B

103

Peptide name

Interleukin-3

Ligandability

Cysteine 35 of Interleukin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Interleukin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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