a tool for identifying drug-targetable redox-active disulphides

Guanine nucleotide-binding protein G(i) subunit alpha-3

Intermolecular

Cysteine 305 and cysteine 305 L

A redox-regulated disulphide may form between two units of Guanine nucleotide-binding protein G(i) subunit alpha-3 at cysteines 305 and 305. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

structure of lgn gl4/galphai3 complex

Structure deposition date

2012-07-18

Thiol separation (Å)

9

Half-sphere exposure sum ?

46

Minimum pK_a ?

11

% buried

54

Peptide A name

Guanine nucleotide-binding protein G(i) subunit alpha-3

Peptide B name

Guanine nucleotide-binding protein G(i) subunit alpha-3

Peptide A accession

Peptide B accession

Peptide A residue number

305

Peptide B residue number

305

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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