ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Steryl-sulfatase

Intramolecular
Cysteine 563 and cysteine 572
Cysteine 562 and cysteine 570
Cysteine 481 and cysteine 487
Cysteine 141 and cysteine 148
Cysteine 446 and cysteine 489
Cysteine 170 and cysteine 242
Cysteine 562 and cysteine 563
Cysteine 570 and cysteine 572
Cysteine 563 and cysteine 570
Cysteine 562 and cysteine 572
More...
Cysteine 487 and cysteine 489
Cysteine 446 and cysteine 487
Cysteine 446 and cysteine 481
A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 563 and 572.

Details

Redox score ?
86
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
563
Residue number B
572
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 563 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 562 and 570.

Details

Redox score ?
85
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
562
Residue number B
570
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 562 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 570 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 481 and 487.

Details

Redox score ?
83
PDB code
8eg3
Structure name
structure of human placental steroid (estrone/dhea) sulfatase at 2
Structure deposition date
2022-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
481
Residue number B
487
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 481 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 141 and 148.

Details

Redox score ?
80
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
141
Residue number B
148
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 141 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 446 and 489.

Details

Redox score ?
80
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
446
Residue number B
489
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 446 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 170 and 242.

Details

Redox score ?
79
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
170
Residue number B
242
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 170 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 562 and 563. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
562
Residue number B
563
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 562 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 563 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 570 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
570
Residue number B
572
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 570 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 563 and 570. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
8eg3
Structure name
structure of human placental steroid (estrone/dhea) sulfatase at 2
Structure deposition date
2022-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
563
Residue number B
570
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 563 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 570 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 562 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
562
Residue number B
572
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 562 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 487 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
8eg3
Structure name
structure of human placental steroid (estrone/dhea) sulfatase at 2
Structure deposition date
2022-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
487
Residue number B
489
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 487 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 446 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1p49
Structure name
structure of human placental estrone/dhea sulfatase
Structure deposition date
2003-04-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
446
Residue number B
487
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 446 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Steryl-sulfatase between cysteines 446 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8eg3
Structure name
structure of human placental steroid (estrone/dhea) sulfatase at 2
Structure deposition date
2022-09-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08842
Residue number A
446
Residue number B
481
Peptide name
Steryl-sulfatase

Ligandability

Cysteine 446 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Steryl-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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