ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-6 receptor subunit alpha

Intermolecular
Cysteine 176 and cysteine 121
Cysteine 165 and cysteine 132
Intramolecular
Cysteine 211 and cysteine 692
Cysteine 165 and cysteine 176
Cysteine 47 and cysteine 96
Cysteine 121 and cysteine 132
Cysteine 25 and cysteine 193
Cysteine 132 and cysteine 176
Cysteine 121 and cysteine 165
Cysteine 165 and cysteine 193
Cysteine 176 and cysteine 193
A redox-regulated disulphide may form between two units of Interleukin-6 receptor subunit alpha at cysteines 176 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7dc8
Structure name
crystal structure of switch ab fab and hil6r in complex with atp
Structure deposition date
2020-10-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-6 receptor subunit alpha
Peptide B name
Interleukin-6 receptor subunit alpha
Peptide A accession
P08887
Peptide B accession
P08887
Peptide A residue number
176
Peptide B residue number
121

Ligandability

Cysteine 176 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Interleukin-6 receptor subunit alpha at cysteines 165 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7dc8
Structure name
crystal structure of switch ab fab and hil6r in complex with atp
Structure deposition date
2020-10-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-6 receptor subunit alpha
Peptide B name
Interleukin-6 receptor subunit alpha
Peptide A accession
P08887
Peptide B accession
P08887
Peptide A residue number
165
Peptide B residue number
132

Ligandability

Cysteine 165 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 211 and 692 (192 and 692 respectively in this structure).

Details

Redox score ?
87
PDB code
1n26
Structure name
crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain
Structure deposition date
2002-10-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
211
Residue number B
692
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 211 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 692 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 692 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 165 and 176 (146 and 157 respectively in this structure).

Details

Redox score ?
86
PDB code
1p9m
Structure name
crystal structure of the hexameric human il-6/il-6 alpha receptor/gp130 complex
Structure deposition date
2003-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
165
Residue number B
176
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 165 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 47 and 96 (28 and 77 respectively in this structure).

Details

Redox score ?
85
PDB code
1n26
Structure name
crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain
Structure deposition date
2002-10-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
47
Residue number B
96
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 47 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 121 and 132.

Details

Redox score ?
85
PDB code
7dc8
Structure name
crystal structure of switch ab fab and hil6r in complex with atp
Structure deposition date
2020-10-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
121
Residue number B
132
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 121 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 25 and 193 (6 and 174 respectively in this structure).

Details

Redox score ?
81
PDB code
1n26
Structure name
crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain
Structure deposition date
2002-10-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
25
Residue number B
193
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 25 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 132 and 176 (113 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5fuc
Structure name
biophysical and cellular characterisation of a junctional epitope antibody that locks il-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Structure deposition date
2016-01-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
132
Residue number B
176
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 132 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 121 and 165 (102 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5fuc
Structure name
biophysical and cellular characterisation of a junctional epitope antibody that locks il-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Structure deposition date
2016-01-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08887
Residue number A
121
Residue number B
165
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 121 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 165 and 193 (146 and 174 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5fuc
Structure name
biophysical and cellular characterisation of a junctional epitope antibody that locks il-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Structure deposition date
2016-01-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
nan
Peptide accession
P08887
Residue number A
165
Residue number B
193
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 165 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit alpha between cysteines 176 and 193 (157 and 174 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
1p9m
Structure name
crystal structure of the hexameric human il-6/il-6 alpha receptor/gp130 complex
Structure deposition date
2003-05-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
nan
Peptide accession
P08887
Residue number A
176
Residue number B
193
Peptide name
Interleukin-6 receptor subunit alpha

Ligandability

Cysteine 176 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Interleukin-6 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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