5-hydroxytryptamine receptor 1A
Intramolecular
Cysteine 109 and cysteine 187
Cysteine 371 and cysteine 375
Cysteine 119 and cysteine 120
Cysteine 49 and cysteine 56
7e2y R 109 R 187
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1A between cysteines 109 and 187.
Details
Redox score ?
87
PDB code
7e2y
Structure name
serotonin-bound serotonin 1a (5-ht1a) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08908
Residue number A
109
Residue number B
187
Peptide name
5-hydroxytryptamine receptor 1A
Ligandability
Cysteine 109 of 5-hydroxytryptamine receptor 1A
Cysteine 187 of 5-hydroxytryptamine receptor 1A
7e2z R 371 R 375
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1A between cysteines 371 and 375.
Details
Redox score ?
64
PDB code
7e2z
Structure name
aripiprazole-bound serotonin 1a (5-ht1a) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
30
Minimum pKa ?
9
% buried
0
Peptide accession
P08908
Residue number A
371
Residue number B
375
Peptide name
5-hydroxytryptamine receptor 1A
Ligandability
Cysteine 371 of 5-hydroxytryptamine receptor 1A
Cysteine 375 of 5-hydroxytryptamine receptor 1A
7e2y R 119 R 120
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1A between cysteines 119 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7e2y
Structure name
serotonin-bound serotonin 1a (5-ht1a) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
91
Peptide accession
P08908
Residue number A
119
Residue number B
120
Peptide name
5-hydroxytryptamine receptor 1A
Ligandability
Cysteine 119 of 5-hydroxytryptamine receptor 1A
Cysteine 120 of 5-hydroxytryptamine receptor 1A
7e2x R 49 R 56
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1A between cysteines 49 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7e2x
Structure name
apo serotonin 1a (5-ht1a) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
42
Peptide accession
P08908
Residue number A
49
Residue number B
56
Peptide name
5-hydroxytryptamine receptor 1A
Ligandability
Cysteine 49 of 5-hydroxytryptamine receptor 1A
Cysteine 56 of 5-hydroxytryptamine receptor 1A
If this tool was useful for finding a disulphide, please cite: