ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Muscarinic acetylcholine receptor M5

Intramolecular
Cysteine 103 and cysteine 183
Cysteine 468 and cysteine 471
Cysteine 494 and cysteine 498
A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M5 between cysteines 103 and 183.

Details

Redox score ?
85
PDB code
6ol9
Structure name
structure of the m5 muscarinic acetylcholine receptor (m5-t4l) bound to tiotropium
Structure deposition date
2019-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08912
Residue number A
103
Residue number B
183
Peptide name
Muscarinic acetylcholine receptor M5

Ligandability

Cysteine 103 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M5 between cysteines 468 and 471.

Details

Redox score ?
84
PDB code
6ol9
Structure name
structure of the m5 muscarinic acetylcholine receptor (m5-t4l) bound to tiotropium
Structure deposition date
2019-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P08912
Residue number A
468
Residue number B
471
Peptide name
Muscarinic acetylcholine receptor M5

Ligandability

Cysteine 468 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M5 between cysteines 494 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6ol9
Structure name
structure of the m5 muscarinic acetylcholine receptor (m5-t4l) bound to tiotropium
Structure deposition date
2019-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
44
Peptide accession
P08912
Residue number A
494
Residue number B
498
Peptide name
Muscarinic acetylcholine receptor M5

Ligandability

Cysteine 494 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 498 of Muscarinic acetylcholine receptor M5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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