Fibroblast growth factor 2

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Fibroblast growth factor 2 at cysteines 211 and 211 (69 and 69 respectively in this structure).

Details

Redox score ?

PDB code

5x1o

Structure name

pi(4,5)p2 lipid binding induced a reorientation of fgf2 molecules near membrane surface to facilitate the unconventional oligomerization- dependent secretion process as revealed by a combined ftir/nmr/x-ray study

Structure deposition date

2017-01-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Fibroblast growth factor 2

Peptide B name

Fibroblast growth factor 2

Peptide A accession

P09038

Peptide B accession

P09038

Peptide A residue number

211

Peptide B residue number

211

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor 2 between cysteines 229 and 234 (87 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?