ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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U1 small nuclear ribonucleoprotein C

Intramolecular
Cysteine 6 and cysteine 9
Cysteine 6 and cysteine 25 L
Cysteine 9 and cysteine 25 L
Cysteine 33 and cysteine 36
A redox-regulated disulphide may form within U1 small nuclear ribonucleoprotein C between cysteines 6 and 9.

Details

Redox score ?
83
PDB code
4pjo
Structure name
minimal u1 snrnp
Structure deposition date
2014-05-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
70
Peptide accession
P09234
Residue number A
6
Residue number B
9
Peptide name
U1 small nuclear ribonucleoprotein C

Ligandability

Cysteine 6 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 9 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within U1 small nuclear ribonucleoprotein C between cysteines 6 and 25. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4pjo
Structure name
minimal u1 snrnp
Structure deposition date
2014-05-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
84
Peptide accession
P09234
Residue number A
6
Residue number B
25
Peptide name
U1 small nuclear ribonucleoprotein C

Ligandability

Cysteine 6 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within U1 small nuclear ribonucleoprotein C between cysteines 9 and 25. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4pjo
Structure name
minimal u1 snrnp
Structure deposition date
2014-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
11
% buried
69
Peptide accession
P09234
Residue number A
9
Residue number B
25
Peptide name
U1 small nuclear ribonucleoprotein C

Ligandability

Cysteine 9 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within U1 small nuclear ribonucleoprotein C between cysteines 33 and 36.

Details

Redox score ?
nan
PDB code
6eld
Structure name
crystal structure of tia-1 rrm1 in complex with u1c
Structure deposition date
2017-09-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
42
Peptide accession
P09234
Residue number A
33
Residue number B
36
Peptide name
U1 small nuclear ribonucleoprotein C

Ligandability

Cysteine 33 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of U1 small nuclear ribonucleoprotein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 in protein A could not be asigned to a Uniprot residue.
Cysteine 36 in protein B could not be asigned to a Uniprot residue.
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