ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CD48 antigen

Intramolecular
Cysteine 145 and cysteine 151
Cysteine 115 and cysteine 179
A redox-regulated disulphide may form within CD48 antigen between cysteines 145 and 151 (122 and 162 respectively in this structure).

Details

Redox score ?
nan
PDB code
2dru
Structure name
crystal structure and binding properties of the cd2 and cd244 (2b4) binding protein, cd48
Structure deposition date
2006-06-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10252
Residue number A
145
Residue number B
151
Peptide name
CD48 antigen

Ligandability

Cysteine 145 of CD48 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of CD48 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 162 has been assigned to correct residue.
A redox-regulated disulphide may form within CD48 antigen between cysteines 115 and 179.

Details

Redox score ?
nan
PDB code
2dru
Structure name
crystal structure and binding properties of the cd2 and cd244 (2b4) binding protein, cd48
Structure deposition date
2006-06-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10252
Residue number A
115
Residue number B
179
Peptide name
CD48 antigen

Ligandability

Cysteine 115 of CD48 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of CD48 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 in protein A could not be asigned to a Uniprot residue.
Cysteine 179 in protein B could not be asigned to a Uniprot residue.
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