ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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High mobility group protein B1

Intramolecular
Cysteine 23 and cysteine 45 L
A redox-regulated disulphide may form within High mobility group protein B1 between cysteines 23 and 45 (22 and 44 respectively in this structure).

Details

Redox score ?
77
PDB code
4qr9
Structure name
crystal structure of two hmgb1 box a domains cooperating to underwind and kink a dna
Structure deposition date
2014-06-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
78
Peptide accession
P63159
Residue number A
23
Residue number B
45
Peptide name
High mobility group protein B1

Ligandability

Cysteine 23 of High mobility group protein B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 45 of High mobility group protein B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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