ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glycodelin

Intramolecular
Cysteine 84 and cysteine 178
Cysteine 124 and cysteine 137
A redox-regulated disulphide may form within Glycodelin between cysteines 84 and 178 (66 and 160 respectively in this structure).

Details

Redox score ?
91
PDB code
4r0b
Structure name
structure of dimeric human glycodelin
Structure deposition date
2014-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09466
Residue number A
84
Residue number B
178
Peptide name
Glycodelin

Ligandability

Cysteine 84 of Glycodelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Glycodelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycodelin between cysteines 124 and 137 (106 and 119 respectively in this structure).

Details

Redox score ?
78
PDB code
4r0b
Structure name
structure of dimeric human glycodelin
Structure deposition date
2014-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09466
Residue number A
124
Residue number B
137
Peptide name
Glycodelin

Ligandability

Cysteine 124 of Glycodelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Glycodelin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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