Guanine nucleotide-binding protein G(o) subunit alpha
Intermolecular
Cysteine 124 of Muscarinic acetylcholine receptor M2 and cysteine 351
Cysteine 133 of Muscarinic acetylcholine receptor M4 and cysteine 351
Cysteine 443 of Muscarinic acetylcholine receptor M2 and cysteine 351
Cysteine 140 of Rhodopsin and cysteine 351
7t90 A 124 B 351
A redox-regulated disulphide may form between cysteine 124 of Muscarinic acetylcholine receptor M2 and cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha.
Details
Redox score ?
72
PDB code
7t90
Structure name
cryo-em structure of ach-bound m2r-go signaling complex in s2 state
Structure deposition date
2021-12-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
6
% buried
79
Peptide A name
Muscarinic acetylcholine receptor M2
Peptide B name
Guanine nucleotide-binding protein G(o) subunit alpha
Peptide A accession
P08172
Peptide B accession
P09471
Peptide A residue number
124
Peptide B residue number
351
Ligandability
Cysteine 124 of Muscarinic acetylcholine receptor M2
Cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha
8e9x A 133 B 222
A redox-regulated disulphide may form between cysteine 133 of Muscarinic acetylcholine receptor M4 and cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha (133 and 222 respectively in this structure).
Details
Redox score ?
68
PDB code
8e9x
Structure name
cryoem structure of minigo-coupled hm4di in complex with dcz
Structure deposition date
2022-08-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
86
Peptide A name
Muscarinic acetylcholine receptor M4
Peptide B name
Guanine nucleotide-binding protein G(o) subunit alpha
Peptide A accession
P08173
Peptide B accession
P09471
Peptide A residue number
133
Peptide B residue number
351
Ligandability
Cysteine 133 of Muscarinic acetylcholine receptor M4
Cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha
6oik R 443 A 351
A redox-regulated disulphide may form between cysteine 443 of Muscarinic acetylcholine receptor M2 and cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6oik
Structure name
muscarinic acetylcholine receptor 2-go complex
Structure deposition date
2019-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
88
Peptide A name
Muscarinic acetylcholine receptor M2
Peptide B name
Guanine nucleotide-binding protein G(o) subunit alpha
Peptide A accession
P08172
Peptide B accession
P09471
Peptide A residue number
443
Peptide B residue number
351
Ligandability
Cysteine 443 of Muscarinic acetylcholine receptor M2
Cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha
6fuf A 140 B 351
A redox-regulated disulphide may form between cysteine 140 of Rhodopsin and cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6fuf
Structure name
crystal structure of the rhodopsin-mini-go complex
Structure deposition date
2018-02-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
76
Peptide A name
Rhodopsin
Peptide B name
Guanine nucleotide-binding protein G(o) subunit alpha
Peptide A accession
P02699
Peptide B accession
P09471
Peptide A residue number
140
Peptide B residue number
351
Ligandability
Cysteine 140 of Rhodopsin
Cysteine 351 of Guanine nucleotide-binding protein G(o) subunit alpha
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