ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Clathrin light chain B

Intermolecular
Cysteine 1569 of Clathrin heavy chain 1 and cysteine 198 L
Cysteine 1573 of Clathrin heavy chain 1 and cysteine 198 L
Cysteine 1565 of Clathrin heavy chain 1 and cysteine 198 L
A redox-regulated disulphide may form between cysteine 1569 of Clathrin heavy chain 1 and cysteine 198 of Clathrin light chain B. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6wcj
Structure name
asymmetric vertex of the clathrin minicoat cage
Structure deposition date
2020-03-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
88
Peptide A name
Clathrin heavy chain 1
Peptide B name
Clathrin light chain B
Peptide A accession
P49951
Peptide B accession
P04975
Peptide A residue number
1569
Peptide B residue number
198

Ligandability

Cysteine 1569 of Clathrin heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Clathrin light chain B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 1573 of Clathrin heavy chain 1 and cysteine 198 of Clathrin light chain B. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6wcj
Structure name
asymmetric vertex of the clathrin minicoat cage
Structure deposition date
2020-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
85
Peptide A name
Clathrin heavy chain 1
Peptide B name
Clathrin light chain B
Peptide A accession
P49951
Peptide B accession
P04975
Peptide A residue number
1573
Peptide B residue number
198

Ligandability

Cysteine 1573 of Clathrin heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Clathrin light chain B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 1565 of Clathrin heavy chain 1 and cysteine 198 of Clathrin light chain B. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6wcj
Structure name
asymmetric vertex of the clathrin minicoat cage
Structure deposition date
2020-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
76
Peptide A name
Clathrin heavy chain 1
Peptide B name
Clathrin light chain B
Peptide A accession
P49951
Peptide B accession
P04975
Peptide A residue number
1565
Peptide B residue number
198

Ligandability

Cysteine 1565 of Clathrin heavy chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Clathrin light chain B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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