Macrophage colony-stimulating factor 1
Intermolecular
Cysteine 63 and cysteine 63
Intramolecular
Cysteine 134 and cysteine 178
Cysteine 80 and cysteine 171
Cysteine 39 and cysteine 122
Cysteine 80 and cysteine 178
Cysteine 134 and cysteine 171
Cysteine 171 and cysteine 178
Cysteine 80 and cysteine 134
4wrl B 31 D 31
A redox-regulated disulphide may form between two units of Macrophage colony-stimulating factor 1 at cysteines 63 and 63 (31 and 31 respectively in this structure).
Details
Redox score ?
85
PDB code
4wrl
Structure name
structure of the human csf-1:csf-1r complex
Structure deposition date
2014-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Macrophage colony-stimulating factor 1
Peptide B name
Macrophage colony-stimulating factor 1
Peptide A accession
P09603
Peptide B accession
P09603
Peptide A residue number
63
Peptide B residue number
63
Ligandability
4fa8 G 102 G 146
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 134 and 178 (102 and 146 respectively in this structure).
Details
Redox score ?
88
PDB code
4fa8
Structure name
multi-pronged modulation of cytokine signaling
Structure deposition date
2012-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
134
Residue number B
178
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 134 of Macrophage colony-stimulating factor 1
Cysteine 178 of Macrophage colony-stimulating factor 1
3uf2 C 48 C 139
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 80 and 171 (48 and 139 respectively in this structure).
Details
Redox score ?
84
PDB code
3uf2
Structure name
crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine
Structure deposition date
2011-10-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
80
Residue number B
171
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 80 of Macrophage colony-stimulating factor 1
Cysteine 171 of Macrophage colony-stimulating factor 1
5lxf A 7 A 90
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 39 and 122 (7 and 90 respectively in this structure).
Details
Redox score ?
83
PDB code
5lxf
Structure name
crystal structure of the human macrophage colony stimulating factor m- csf_c31s variant
Structure deposition date
2016-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
39
Residue number B
122
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 39 of Macrophage colony-stimulating factor 1
Cysteine 122 of Macrophage colony-stimulating factor 1
5lxf B 48 B 146
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 80 and 178 (48 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5lxf
Structure name
crystal structure of the human macrophage colony stimulating factor m- csf_c31s variant
Structure deposition date
2016-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
80
Residue number B
178
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 80 of Macrophage colony-stimulating factor 1
Cysteine 178 of Macrophage colony-stimulating factor 1
4fa8 F 102 F 139
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 134 and 171 (102 and 139 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4fa8
Structure name
multi-pronged modulation of cytokine signaling
Structure deposition date
2012-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
134
Residue number B
171
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 134 of Macrophage colony-stimulating factor 1
Cysteine 171 of Macrophage colony-stimulating factor 1
3uez G 139 G 146
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 171 and 178 (139 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3uez
Structure name
crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the viral receptor barf1
Structure deposition date
2011-10-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
171
Residue number B
178
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 171 of Macrophage colony-stimulating factor 1
Cysteine 178 of Macrophage colony-stimulating factor 1
5lxf A 48 A 102
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 between cysteines 80 and 134 (48 and 102 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5lxf
Structure name
crystal structure of the human macrophage colony stimulating factor m- csf_c31s variant
Structure deposition date
2016-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09603
Residue number A
80
Residue number B
134
Peptide name
Macrophage colony-stimulating factor 1
Ligandability
Cysteine 80 of Macrophage colony-stimulating factor 1
Cysteine 134 of Macrophage colony-stimulating factor 1
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