ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet-derived growth factor receptor beta

Intramolecular
Cysteine 235 and cysteine 291
Cysteine 54 and cysteine 100
Cysteine 149 and cysteine 190
Cysteine 15 and cysteine 16
A redox-regulated disulphide may form within Platelet-derived growth factor receptor beta between cysteines 235 and 291.

Details

Redox score ?
81
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09619
Residue number A
235
Residue number B
291
Peptide name
Platelet-derived growth factor receptor beta

Ligandability

Cysteine 235 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor beta between cysteines 54 and 100.

Details

Redox score ?
80
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09619
Residue number A
54
Residue number B
100
Peptide name
Platelet-derived growth factor receptor beta

Ligandability

Cysteine 54 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor beta between cysteines 149 and 190.

Details

Redox score ?
80
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09619
Residue number A
149
Residue number B
190
Peptide name
Platelet-derived growth factor receptor beta

Ligandability

Cysteine 149 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-derived growth factor receptor beta between cysteines 15 and 16.

Details

Redox score ?
nan
PDB code
1gq5
Structure name
structural determinants of the nherf interaction with beta2-ar and pdgfr
Structure deposition date
2001-11-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
18
Peptide accession
P09619
Residue number A
15
Residue number B
16
Peptide name
Platelet-derived growth factor receptor beta

Ligandability

Cysteine 15 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 16 of Platelet-derived growth factor receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 15 in protein A could not be asigned to a Uniprot residue.
Cysteine 16 in protein B could not be asigned to a Uniprot residue.
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