DNA polymerase alpha catalytic subunit
Intermolecular
Cysteine 1281 and cysteine 392 of DNA polymerase alpha subunit B L
Intramolecular
Cysteine 1348 and cysteine 1353
Cysteine 1353 and cysteine 1371
Cysteine 1283 and cysteine 1310 L
Cysteine 1353 and cysteine 1374
Cysteine 1283 and cysteine 1315 L
Cysteine 1283 and cysteine 1286 L
Cysteine 1286 and cysteine 1315 L
Cysteine 1286 and cysteine 1310 L
Cysteine 1310 and cysteine 1315 L
More...Cysteine 1371 and cysteine 1374
Cysteine 1348 and cysteine 1374
Cysteine 1348 and cysteine 1371
Cysteine 1281 and cysteine 1283 L
Cysteine 1281 and cysteine 1286 L
Cysteine 377 and cysteine 514 L
Cysteine 376 and cysteine 514 L
Cysteine 1276 and cysteine 1393
Cysteine 1281 and cysteine 1310 L
Cysteine 376 and cysteine 377
Cysteine 514 and cysteine 686 L
Cysteine 377 and cysteine 686
Cysteine 691 and cysteine 757
5exr G 1281 H 392
A redox-regulated disulphide may form between cysteine 1281 of DNA polymerase alpha catalytic subunit and cysteine 392 of DNA polymerase alpha subunit B.
Details
Redox score ?
71
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
74
Peptide A name
DNA polymerase alpha catalytic subunit
Peptide B name
DNA polymerase alpha subunit B
Peptide A accession
P09884
Peptide B accession
Q14181
Peptide A residue number
1281
Peptide B residue number
392
Ligandability
Cysteine 1281 of DNA polymerase alpha catalytic subunit
Cysteine 392 of DNA polymerase alpha subunit B
5exr G 1348 G 1353
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1348 and 1353.
Details
Redox score ?
96
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
1
% buried
63
Peptide accession
P09884
Residue number A
1348
Residue number B
1353
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1348 of DNA polymerase alpha catalytic subunit
Cysteine 1353 of DNA polymerase alpha catalytic subunit
5exr G 1353 G 1371
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1353 and 1371.
Details
Redox score ?
91
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
1
% buried
56
Peptide accession
P09884
Residue number A
1353
Residue number B
1371
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1353 of DNA polymerase alpha catalytic subunit
Cysteine 1371 of DNA polymerase alpha catalytic subunit
5exr G 1283 G 1310
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1283 and 1310.
Details
Redox score ?
87
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
11
Peptide accession
P09884
Residue number A
1283
Residue number B
1310
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1283 of DNA polymerase alpha catalytic subunit
Cysteine 1310 of DNA polymerase alpha catalytic subunit
5exr G 1353 G 1374
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1353 and 1374.
Details
Redox score ?
87
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
1
% buried
47
Peptide accession
P09884
Residue number A
1353
Residue number B
1374
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1353 of DNA polymerase alpha catalytic subunit
Cysteine 1374 of DNA polymerase alpha catalytic subunit
5exr C 1283 C 1315
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1283 and 1315.
Details
Redox score ?
87
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
6
Peptide accession
P09884
Residue number A
1283
Residue number B
1315
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1283 of DNA polymerase alpha catalytic subunit
Cysteine 1315 of DNA polymerase alpha catalytic subunit
5exr C 1283 C 1286
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1283 and 1286.
Details
Redox score ?
84
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
6
Peptide accession
P09884
Residue number A
1283
Residue number B
1286
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1283 of DNA polymerase alpha catalytic subunit
Cysteine 1286 of DNA polymerase alpha catalytic subunit
5exr G 1286 G 1315
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1286 and 1315.
Details
Redox score ?
83
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
P09884
Residue number A
1286
Residue number B
1315
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1286 of DNA polymerase alpha catalytic subunit
Cysteine 1315 of DNA polymerase alpha catalytic subunit
5exr G 1286 G 1310
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1286 and 1310.
Details
Redox score ?
82
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
6
Peptide accession
P09884
Residue number A
1286
Residue number B
1310
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1286 of DNA polymerase alpha catalytic subunit
Cysteine 1310 of DNA polymerase alpha catalytic subunit
5exr G 1310 G 1315
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1310 and 1315.
Details
Redox score ?
81
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
6
Peptide accession
P09884
Residue number A
1310
Residue number B
1315
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1310 of DNA polymerase alpha catalytic subunit
Cysteine 1315 of DNA polymerase alpha catalytic subunit
5exr G 1371 G 1374
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1371 and 1374.
Details
Redox score ?
75
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
44
Peptide accession
P09884
Residue number A
1371
Residue number B
1374
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1371 of DNA polymerase alpha catalytic subunit
Cysteine 1374 of DNA polymerase alpha catalytic subunit
5exr G 1348 G 1374
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1348 and 1374.
Details
Redox score ?
74
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
51
Peptide accession
P09884
Residue number A
1348
Residue number B
1374
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1348 of DNA polymerase alpha catalytic subunit
Cysteine 1374 of DNA polymerase alpha catalytic subunit
5exr G 1348 G 1371
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1348 and 1371.
Details
Redox score ?
71
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
60
Peptide accession
P09884
Residue number A
1348
Residue number B
1371
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1348 of DNA polymerase alpha catalytic subunit
Cysteine 1371 of DNA polymerase alpha catalytic subunit
5exr C 1281 C 1283
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1281 and 1283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
44
Peptide accession
P09884
Residue number A
1281
Residue number B
1283
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1281 of DNA polymerase alpha catalytic subunit
Cysteine 1283 of DNA polymerase alpha catalytic subunit
7u5c C 1281 C 1286
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1281 and 1286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
49
Peptide accession
P09884
Residue number A
1281
Residue number B
1286
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1281 of DNA polymerase alpha catalytic subunit
Cysteine 1286 of DNA polymerase alpha catalytic subunit
5exr C 377 C 514
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 377 and 514. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
P09884
Residue number A
377
Residue number B
514
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 377 of DNA polymerase alpha catalytic subunit
Cysteine 514 of DNA polymerase alpha catalytic subunit
4qcl A 376 A 514
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 376 and 514. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4qcl
Structure name
crystal structure of the catalytic core of human dna polymerase alpha in ternary complex with an rna-primed dna template and dctp
Structure deposition date
2014-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
98
Peptide accession
P09884
Residue number A
376
Residue number B
514
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 376 of DNA polymerase alpha catalytic subunit
Cysteine 514 of DNA polymerase alpha catalytic subunit
5exr C 1276 C 1393
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1276 and 1393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
85
Peptide accession
P09884
Residue number A
1276
Residue number B
1393
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1276 of DNA polymerase alpha catalytic subunit
Cysteine 1393 of DNA polymerase alpha catalytic subunit
5exr C 1281 C 1310
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 1281 and 1310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
44
Peptide accession
P09884
Residue number A
1281
Residue number B
1310
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 1281 of DNA polymerase alpha catalytic subunit
Cysteine 1310 of DNA polymerase alpha catalytic subunit
4qcl A 376 A 377
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 376 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4qcl
Structure name
crystal structure of the catalytic core of human dna polymerase alpha in ternary complex with an rna-primed dna template and dctp
Structure deposition date
2014-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
14
% buried
99
Peptide accession
P09884
Residue number A
376
Residue number B
377
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 376 of DNA polymerase alpha catalytic subunit
Cysteine 377 of DNA polymerase alpha catalytic subunit
4q5v A 514 A 686
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 514 and 686. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
4q5v
Structure name
crystal structure of the catalytic core of human dna polymerase alpha in ternary complex with an rna-primed dna template and aphidicolin
Structure deposition date
2014-04-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
100
Peptide accession
P09884
Residue number A
514
Residue number B
686
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 514 of DNA polymerase alpha catalytic subunit
Cysteine 686 of DNA polymerase alpha catalytic subunit
5iud A 377 A 686
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 377 and 686. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
5iud
Structure name
human dna polymerase alpha in binary complex with a dna:dna template- primer
Structure deposition date
2016-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
96
Peptide accession
P09884
Residue number A
377
Residue number B
686
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 377 of DNA polymerase alpha catalytic subunit
Cysteine 686 of DNA polymerase alpha catalytic subunit
5iud D 691 D 757
A redox-regulated disulphide may form within DNA polymerase alpha catalytic subunit between cysteines 691 and 757. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
5iud
Structure name
human dna polymerase alpha in binary complex with a dna:dna template- primer
Structure deposition date
2016-03-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
90
Peptide accession
P09884
Residue number A
691
Residue number B
757
Peptide name
DNA polymerase alpha catalytic subunit
Ligandability
Cysteine 691 of DNA polymerase alpha catalytic subunit
Cysteine 757 of DNA polymerase alpha catalytic subunit
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