ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon-induced protein with tetratricopeptide repeats 2

Intramolecular
Cysteine 285 and cysteine 289 L
Cysteine 54 and cysteine 73
Cysteine 289 and cysteine 290 L
Cysteine 285 and cysteine 290
Cysteine 140 and cysteine 160
A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 2 between cysteines 285 and 289.

Details

Redox score ?
66
PDB code
4g1t
Structure name
crystal structure of interferon-stimulated gene 54
Structure deposition date
2012-07-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
76
Peptide accession
P09913
Residue number A
285
Residue number B
289
Peptide name
Interferon-induced protein with tetratricopeptide repeats 2

Ligandability

Cysteine 285 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 2 between cysteines 54 and 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4g1t
Structure name
crystal structure of interferon-stimulated gene 54
Structure deposition date
2012-07-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
49
Peptide accession
P09913
Residue number A
54
Residue number B
73
Peptide name
Interferon-induced protein with tetratricopeptide repeats 2

Ligandability

Cysteine 54 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 2 between cysteines 289 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4g1t
Structure name
crystal structure of interferon-stimulated gene 54
Structure deposition date
2012-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
6
% buried
74
Peptide accession
P09913
Residue number A
289
Residue number B
290
Peptide name
Interferon-induced protein with tetratricopeptide repeats 2

Ligandability

Cysteine 289 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 2 between cysteines 285 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4g1t
Structure name
crystal structure of interferon-stimulated gene 54
Structure deposition date
2012-07-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
76
Peptide accession
P09913
Residue number A
285
Residue number B
290
Peptide name
Interferon-induced protein with tetratricopeptide repeats 2

Ligandability

Cysteine 285 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 2 between cysteines 140 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4g1t
Structure name
crystal structure of interferon-stimulated gene 54
Structure deposition date
2012-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
14
% buried
94
Peptide accession
P09913
Residue number A
140
Residue number B
160
Peptide name
Interferon-induced protein with tetratricopeptide repeats 2

Ligandability

Cysteine 140 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Interferon-induced protein with tetratricopeptide repeats 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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