ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon-induced protein with tetratricopeptide repeats 1

Intramolecular
Cysteine 125 and cysteine 138
Cysteine 138 and cysteine 143
Cysteine 143 and cysteine 163
A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 1 between cysteines 125 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5w5h
Structure name
human ifit1 dimer with m7gppp-aaaa
Structure deposition date
2017-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
11
% buried
54
Peptide accession
P09914
Residue number A
125
Residue number B
138
Peptide name
Interferon-induced protein with tetratricopeptide repeats 1

Ligandability

Cysteine 125 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 1 between cysteines 138 and 143. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5w5i
Structure name
human ifit1 dimer with ppp-aaaa
Structure deposition date
2017-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
58
Peptide accession
P09914
Residue number A
138
Residue number B
143
Peptide name
Interferon-induced protein with tetratricopeptide repeats 1

Ligandability

Cysteine 138 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced protein with tetratricopeptide repeats 1 between cysteines 143 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4hou
Structure name
crystal structure of n-terminal human ifit1
Structure deposition date
2012-10-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
76
Peptide accession
P09914
Residue number A
143
Residue number B
163
Peptide name
Interferon-induced protein with tetratricopeptide repeats 1

Ligandability

Cysteine 143 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Interferon-induced protein with tetratricopeptide repeats 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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