ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin carboxyl-terminal hydrolase isozyme L1

Intramolecular
Cysteine 90 and cysteine 152
Cysteine 47 and cysteine 220
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase isozyme L1 between cysteines 90 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2len
Structure name
solution structure of uchl1 s18y variant
Structure deposition date
2011-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
42
Peptide accession
P09936
Residue number A
90
Residue number B
152
Peptide name
Ubiquitin carboxyl-terminal hydrolase isozyme L1

Ligandability

Cysteine 90 of Ubiquitin carboxyl-terminal hydrolase isozyme L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Ubiquitin carboxyl-terminal hydrolase isozyme L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase isozyme L1 between cysteines 47 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3irt
Structure name
crystal structure of the i93m mutant of ubiquitin carboxy-terminal hydrolase l1
Structure deposition date
2009-08-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
68
Peptide accession
P09936
Residue number A
47
Residue number B
220
Peptide name
Ubiquitin carboxyl-terminal hydrolase isozyme L1

Ligandability

Cysteine 47 of Ubiquitin carboxyl-terminal hydrolase isozyme L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Ubiquitin carboxyl-terminal hydrolase isozyme L1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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