ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukotriene A-4 hydrolase

Intramolecular
Cysteine 136 and cysteine 141
Cysteine 141 and cysteine 147
Cysteine 141 and cysteine 200
Cysteine 147 and cysteine 200
Cysteine 136 and cysteine 200
Cysteine 136 and cysteine 147
A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 136 and 141 (135 and 140 respectively in this structure).

Details

Redox score ?
67
PDB code
2vj8
Structure name
complex of human leukotriene a4 hydrolase with a hydroxamic acid inhibitor
Structure deposition date
2007-12-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IAT6
Residue number A
136
Residue number B
141
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 136 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 141 and 147 (140 and 146 respectively in this structure).

Details

Redox score ?
66
PDB code
3fuf
Structure name
leukotriene a4 hydrolase in complex with fragment 5- fluoroindole and bestatin
Structure deposition date
2009-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09960
Residue number A
141
Residue number B
147
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 141 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 141 and 200 (140 and 199 respectively in this structure).

Details

Redox score ?
65
PDB code
3fhe
Structure name
leukotriene a4 hydrolase complexed with inhibitor n-[3-(4- benzylphenoxy)propyl]-n-methyl-beta-alanine
Structure deposition date
2008-12-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09960
Residue number A
141
Residue number B
200
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 141 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 147 and 200 (146 and 199 respectively in this structure).

Details

Redox score ?
64
PDB code
2vj8
Structure name
complex of human leukotriene a4 hydrolase with a hydroxamic acid inhibitor
Structure deposition date
2007-12-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IAT6
Residue number A
147
Residue number B
200
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 147 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 136 and 200 (135 and 199 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7llq
Structure name
substrate-dependent divergence of leukotriene a4 hydrolase aminopeptidase activity
Structure deposition date
2021-02-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
100
Peptide accession
P09960
Residue number A
136
Residue number B
200
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 136 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukotriene A-4 hydrolase between cysteines 136 and 147 (135 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2vj8
Structure name
complex of human leukotriene a4 hydrolase with a hydroxamic acid inhibitor
Structure deposition date
2007-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IAT6
Residue number A
136
Residue number B
147
Peptide name
Leukotriene A-4 hydrolase

Ligandability

Cysteine 136 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Leukotriene A-4 hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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