a tool for identifying drug-targetable redox-active disulphides

Fructose-bisphosphate aldolase C

Intramolecular

Cysteine 135 and cysteine 178

A redox-regulated disulphide may form within Fructose-bisphosphate aldolase C between cysteines 135 and 178.

Details

Redox score ?

71

PDB code

Structure name

human brain fructose 1,6-(bis)phosphate aldolase (c isozyme)

Structure deposition date

2004-09-14

Thiol separation (Å)

4

Half-sphere exposure sum ?

86

Minimum pK_a ?

8

% buried

96

Peptide accession

Residue number A

135

Residue number B

178

Peptide name

Fructose-bisphosphate aldolase C

Ligandability

Cysteine 135 of Fructose-bisphosphate aldolase C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Fructose-bisphosphate aldolase C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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