ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Complement C4-B

Intermolecular
Cysteine 1394 of Complement C4-A and cysteine 1566
Cysteine 876 of Complement C4-A and cysteine 1590
A redox-regulated disulphide may form between cysteine 1394 of Complement C4-A and cysteine 1566 of Complement C4-B.

Details

Redox score ?
86
PDB code
6ysq
Structure name
the hc4nb8 complement inhibitory nanobody in complex with c4b
Structure deposition date
2020-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Complement C4-A
Peptide B name
Complement C4-B
Peptide A accession
P0C0L4
Peptide B accession
P0C0L5
Peptide A residue number
1394
Peptide B residue number
1566

Ligandability

Cysteine 1394 of Complement C4-A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1566 of Complement C4-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 876 of Complement C4-A and cysteine 1590 of Complement C4-B.

Details

Redox score ?
80
PDB code
6ysq
Structure name
the hc4nb8 complement inhibitory nanobody in complex with c4b
Structure deposition date
2020-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Complement C4-A
Peptide B name
Complement C4-B
Peptide A accession
P0C0L4
Peptide B accession
P0C0L5
Peptide A residue number
876
Peptide B residue number
1590

Ligandability

Cysteine 876 of Complement C4-A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1590 of Complement C4-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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