ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Immunoglobulin lambda constant 1

Intermolecular
Cysteine 105 and cysteine 103 of Immunoglobulin heavy constant gamma 1
Cysteine 105 and cysteine 105
Cysteine 105 and cysteine 221 of Immunoglobulin heavy variable 3-33
Intramolecular
Cysteine 28 and cysteine 87
Cysteine 28 and cysteine 90
A redox-regulated disulphide may form between cysteine 105 of Immunoglobulin lambda constant 1 and cysteine 103 of Immunoglobulin heavy constant gamma 1 (215 and 226 respectively in this structure).

Details

Redox score ?
92
PDB code
1aqk
Structure name
three-dimensional structure of a human fab with high affinity for tetanus toxoid
Structure deposition date
1997-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin lambda constant 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01842
Peptide B accession
P01857
Peptide A residue number
105
Peptide B residue number
103

Ligandability

Cysteine 105 of Immunoglobulin lambda constant 1

Cysteine 103 of Immunoglobulin heavy constant gamma 1

A redox-regulated disulphide may form between two units of Immunoglobulin lambda constant 1 at cysteines 105 and 105 (214 and 214 respectively in this structure).

Details

Redox score ?
88
PDB code
1lil
Structure name
bence jones protein cle, a lambda iii immunoglobulin light- chain dimer
Structure deposition date
1996-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
29
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin lambda constant 1
Peptide B name
Immunoglobulin lambda constant 1
Peptide A accession
P01842
Peptide B accession
P01842
Peptide A residue number
105
Peptide B residue number
105

Ligandability

A redox-regulated disulphide may form between cysteine 105 of Immunoglobulin lambda constant 1 and cysteine 221 of Immunoglobulin heavy variable 3-33 (213 and 221 respectively in this structure).

Details

Redox score ?
87
PDB code
2ig2
Structure name
dir primaerstruktur des kristallisierbaren monoklonalen immunoglobulins igg1 kol
Structure deposition date
1989-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin lambda constant 1
Peptide B name
Immunoglobulin heavy variable 3-33
Peptide A accession
P01842
Peptide B accession
P01772
Peptide A residue number
105
Peptide B residue number
221

Ligandability

Cysteine 105 of Immunoglobulin lambda constant 1

Cysteine 221 of Immunoglobulin heavy variable 3-33

Cysteine 221 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Immunoglobulin lambda constant 1 between cysteines 28 and 87 (134 and 194 respectively in this structure).

Details

Redox score ?
78
PDB code
1lil
Structure name
bence jones protein cle, a lambda iii immunoglobulin light- chain dimer
Structure deposition date
1996-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01842
Residue number A
28
Residue number B
87
Peptide name
Immunoglobulin lambda constant 1

Ligandability

Cysteine 28 of Immunoglobulin lambda constant 1

Cysteine 87 of Immunoglobulin lambda constant 1

A redox-regulated disulphide may form within Immunoglobulin lambda constant 1 between cysteines 28 and 90 (22 and 90 respectively in this structure).

Details

Redox score ?
nan
PDB code
1aqk
Structure name
three-dimensional structure of a human fab with high affinity for tetanus toxoid
Structure deposition date
1997-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01842
Residue number A
28
Residue number B
90
Peptide name
Immunoglobulin lambda constant 1

Ligandability

Cysteine 28 of Immunoglobulin lambda constant 1

Cysteine 90 of Immunoglobulin lambda constant 1

Cysteine 90 in protein B could not be asigned to a Uniprot residue.
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