ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chorionic somatomammotropin hormone

Intramolecular
Cysteine 229 and cysteine 234
Cysteine 44 and cysteine 51
Cysteine 97 and cysteine 212
A redox-regulated disulphide may form within Chorionic somatomammotropin hormone between cysteines 229 and 234 (192 and 197 respectively in this structure).

Details

Redox score ?
88
PDB code
1f6f
Structure name
crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor
Structure deposition date
2000-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16038
Residue number A
229
Residue number B
234
Peptide name
Chorionic somatomammotropin hormone

Ligandability

Cysteine 229 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chorionic somatomammotropin hormone between cysteines 44 and 51 (7 and 14 respectively in this structure).

Details

Redox score ?
88
PDB code
1f6f
Structure name
crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor
Structure deposition date
2000-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16038
Residue number A
44
Residue number B
51
Peptide name
Chorionic somatomammotropin hormone

Ligandability

Cysteine 44 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chorionic somatomammotropin hormone between cysteines 97 and 212 (60 and 175 respectively in this structure).

Details

Redox score ?
82
PDB code
1f6f
Structure name
crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor
Structure deposition date
2000-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P16038
Residue number A
97
Residue number B
212
Peptide name
Chorionic somatomammotropin hormone

Ligandability

Cysteine 97 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Chorionic somatomammotropin hormone

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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