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a tool for identifying drug-targetable redox-active disulphides

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Choriogonadotropin subunit beta 3

Intermolecular
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 113
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 120
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 110
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 120
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 113
Cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 120
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 29
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 29
More...
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 110
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 110
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 110
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 120
Cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 113
Cysteine 56 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 108 of Glycoprotein hormones alpha chain and cysteine 58
Cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 113
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 77
Intramolecular
Cysteine 43 and cysteine 92
Cysteine 54 and cysteine 108
Cysteine 46 and cysteine 130
Cysteine 113 and cysteine 120
Cysteine 58 and cysteine 110
Cysteine 29 and cysteine 77
Cysteine 29 and cysteine 108
Cysteine 54 and cysteine 77
Cysteine 77 and cysteine 108
Cysteine 29 and cysteine 54
Cysteine 29 and cysteine 110
Cysteine 29 and cysteine 58
Cysteine 77 and cysteine 110
Cysteine 43 and cysteine 46
Cysteine 58 and cysteine 77
Cysteine 46 and cysteine 92
A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 113 of Choriogonadotropin subunit beta 3 (87 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
111
Peptide B residue number
113

Ligandability

Cysteine 111 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 120 of Choriogonadotropin subunit beta 3 (87 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
111
Peptide B residue number
120

Ligandability

Cysteine 111 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (7 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
31
Peptide B residue number
58

Ligandability

Cysteine 31 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 110 of Choriogonadotropin subunit beta 3 (7 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
31
Peptide B residue number
110

Ligandability

Cysteine 31 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (31 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
55
Peptide B residue number
58

Ligandability

Cysteine 55 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 120 of Choriogonadotropin subunit beta 3 (156 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
156
Peptide B residue number
120

Ligandability

Cysteine 156 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 113 of Choriogonadotropin subunit beta 3 (59 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
83
Peptide B residue number
113

Ligandability

Cysteine 83 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 120 of Choriogonadotropin subunit beta 3 (131 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
131
Peptide B residue number
120

Ligandability

Cysteine 131 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 29 of Choriogonadotropin subunit beta 3 (7 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
31
Peptide B residue number
29

Ligandability

Cysteine 31 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 29 of Choriogonadotropin subunit beta 3 (31 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
55
Peptide B residue number
29

Ligandability

Cysteine 55 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (59 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
83
Peptide B residue number
58

Ligandability

Cysteine 83 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 110 of Choriogonadotropin subunit beta 3 (59 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
83
Peptide B residue number
110

Ligandability

Cysteine 83 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 110 of Choriogonadotropin subunit beta 3 (87 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
111
Peptide B residue number
110

Ligandability

Cysteine 111 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 110 of Choriogonadotropin subunit beta 3 (31 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
55
Peptide B residue number
110

Ligandability

Cysteine 55 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (87 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
111
Peptide B residue number
58

Ligandability

Cysteine 111 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 120 of Choriogonadotropin subunit beta 3 (59 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
83
Peptide B residue number
120

Ligandability

Cysteine 83 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 113 of Choriogonadotropin subunit beta 3 (156 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
156
Peptide B residue number
113

Ligandability

Cysteine 156 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 56 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (32 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
56
Peptide B residue number
58

Ligandability

Cysteine 56 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 108 of Glycoprotein hormones alpha chain and cysteine 58 of Choriogonadotropin subunit beta 3 (84 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
108
Peptide B residue number
58

Ligandability

Cysteine 108 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 113 of Choriogonadotropin subunit beta 3 (131 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
131
Peptide B residue number
113

Ligandability

Cysteine 131 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 77 of Choriogonadotropin subunit beta 3 (31 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P01215
Peptide B accession
P0DN86
Peptide A residue number
55
Peptide B residue number
77

Ligandability

Cysteine 55 of Glycoprotein hormones alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 43 and 92 (23 and 72 respectively in this structure).

Details

Redox score ?
90
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
43
Residue number B
92
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 43 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 54 and 108 (34 and 88 respectively in this structure).

Details

Redox score ?
86
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
54
Residue number B
108
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 54 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 46 and 130 (26 and 110 respectively in this structure).

Details

Redox score ?
86
PDB code
7fii
Structure name
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
46
Residue number B
130
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 46 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 113 and 120 (93 and 100 respectively in this structure).

Details

Redox score ?
83
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
113
Residue number B
120
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 58 and 110 (38 and 90 respectively in this structure).

Details

Redox score ?
82
PDB code
7fii
Structure name
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
58
Residue number B
110
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 29 and 77 (9 and 57 respectively in this structure).

Details

Redox score ?
81
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
29
Residue number B
77
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 29 and 108 (9 and 88 respectively in this structure).

Details

Redox score ?
70
PDB code
7fii
Structure name
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
29
Residue number B
108
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 54 and 77 (34 and 57 respectively in this structure).

Details

Redox score ?
68
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
54
Residue number B
77
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 54 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 77 and 108 (57 and 88 respectively in this structure).

Details

Redox score ?
67
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
77
Residue number B
108
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 29 and 54 (9 and 34 respectively in this structure).

Details

Redox score ?
64
PDB code
7fii
Structure name
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
29
Residue number B
54
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 29 and 110 (9 and 90 respectively in this structure).

Details

Redox score ?
60
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
29
Residue number B
110
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 29 and 58 (9 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
29
Residue number B
58
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 29 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 77 and 110 (57 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
77
Residue number B
110
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 43 and 46 (23 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
43
Residue number B
46
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 43 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 58 and 77 (38 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7fii
Structure name
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
58
Residue number B
77
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 58 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choriogonadotropin subunit beta 3 between cysteines 46 and 92 (26 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DN86
Residue number A
46
Residue number B
92
Peptide name
Choriogonadotropin subunit beta 3

Ligandability

Cysteine 46 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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