Immunoglobulin gamma-1 heavy chain
Intermolecular
Cysteine 107 of Immunoglobulin kappa constant and cysteine 222
Cysteine 231 and cysteine 231
Cysteine 228 and cysteine 228
Cysteine 239 of Ig-like domain-containing protein and cysteine 222
Cysteine 100 and cysteine 429 of Genome polyprotein
Cysteine 100 and cysteine 505 of Genome polyprotein
Intramolecular
Cysteine 202 and cysteine 323
Cysteine 263 and cysteine 323
Cysteine 369 and cysteine 96
Cysteine 146 and cysteine 202
More...Cysteine 369 and cysteine 427
Cysteine 22 and cysteine 96
Cysteine 22 and cysteine 202
Cysteine 96 and cysteine 202
Cysteine 22 and cysteine 100
Cysteine 344 and cysteine 361
Cysteine 100 and cysteine 100
6oge B 214 C 216
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 222 of Immunoglobulin gamma-1 heavy chain (214 and 216 respectively in this structure).
Details
Redox score ?
94
PDB code
6oge
Structure name
cryo-em structure of her2 extracellular domain-trastuzumab fab- pertuzumab fab complex
Structure deposition date
2019-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Immunoglobulin gamma-1 heavy chain
Peptide A accession
P01834
Peptide B accession
P0DOX5
Peptide A residue number
107
Peptide B residue number
222
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 222 of Immunoglobulin gamma-1 heavy chain
5vu0 A 229 B 229
A redox-regulated disulphide may form between two units of Immunoglobulin gamma-1 heavy chain at cysteines 231 and 231 (229 and 229 respectively in this structure).
Details
Redox score ?
93
PDB code
5vu0
Structure name
crystal structure of the complex between afucosylated/galactosylated human igg1 fc and fc gamma receptor iiia (cd16a) with man5 n-glycans
Structure deposition date
2017-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Immunoglobulin gamma-1 heavy chain
Peptide A accession
P0DOX5
Peptide B accession
P0DOX5
Peptide A residue number
231
Peptide B residue number
231
Ligandability
1hzh H 239 K 239
A redox-regulated disulphide may form between two units of Immunoglobulin gamma-1 heavy chain at cysteines 228 and 228 (239 and 239 respectively in this structure).
Details
Redox score ?
89
PDB code
1hzh
Structure name
crystal structure of the intact human igg b12 with broad and potent activity against primary hiv-1 isolates: a template for hiv vaccine design
Structure deposition date
2001-01-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Immunoglobulin gamma-1 heavy chain
Peptide A accession
P0DOX5
Peptide B accession
P0DOX5
Peptide A residue number
228
Peptide B residue number
228
Ligandability
6bft B 214 A 226
A redox-regulated disulphide may form between cysteine 239 of Ig-like domain-containing protein and cysteine 222 of Immunoglobulin gamma-1 heavy chain (214 and 226 respectively in this structure).
Details
Redox score ?
89
PDB code
6bft
Structure name
structure of bevacizumab fab mutant in complex with vegf
Structure deposition date
2017-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
3
Peptide A name
Ig-like domain-containing protein
Peptide B name
Immunoglobulin gamma-1 heavy chain
Peptide A accession
Q8TCD0
Peptide B accession
P0DOX5
Peptide A residue number
239
Peptide B residue number
222
Ligandability
Cysteine 239 of Ig-like domain-containing protein
Cysteine 222 of Immunoglobulin gamma-1 heavy chain
6bkb H 100 E 429
A redox-regulated disulphide may form between cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 429 of Genome polyprotein.
Details
Redox score ?
65
PDB code
6bkb
Structure name
structure of hepatitis c virus envelope glycoprotein e2 core from genotype 6a bound to broadly neutralizing antibody ar3a
Structure deposition date
2017-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Genome polyprotein
Peptide A accession
P0DOX5
Peptide B accession
B9V0E2
Peptide A residue number
100
Peptide B residue number
429
Ligandability
Cysteine 100 of Immunoglobulin gamma-1 heavy chain
Cysteine 429 of Genome polyprotein
Cysteine 100 in protein A could not be asigned to a Uniprot residue.
6bkb H 100 E 503
A redox-regulated disulphide may form between cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 505 of Genome polyprotein (100 and 503 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6bkb
Structure name
structure of hepatitis c virus envelope glycoprotein e2 core from genotype 6a bound to broadly neutralizing antibody ar3a
Structure deposition date
2017-11-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Genome polyprotein
Peptide A accession
P0DOX5
Peptide B accession
B9V0E2
Peptide A residue number
100
Peptide B residue number
505
Ligandability
Cysteine 100 of Immunoglobulin gamma-1 heavy chain
Cysteine 505 of Genome polyprotein
Cysteine 100 in protein A could not be asigned to a Uniprot residue.
8dv1 D 530 D 542
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 202 and 323 (530 and 542 respectively in this structure).
Details
Redox score ?
82
PDB code
8dv1
Structure name
sars-cov-2 wuhan-hu-1-spike-rbd bound to linker variant of affinity matured ace2 mimetic cvd432
Structure deposition date
2022-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
202
Residue number B
323
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 202 of Immunoglobulin gamma-1 heavy chain
Cysteine 323 of Immunoglobulin gamma-1 heavy chain
5o4e A 261 A 321
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 263 and 323 (261 and 321 respectively in this structure).
Details
Redox score ?
81
PDB code
5o4e
Structure name
crystal structure of vegf in complex with heterodimeric fcab janusct6
Structure deposition date
2017-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
263
Residue number B
323
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 263 of Immunoglobulin gamma-1 heavy chain
Cysteine 323 of Immunoglobulin gamma-1 heavy chain
6okq A 22 A 92
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 369 and 96 (22 and 92 respectively in this structure).
Details
Redox score ?
79
PDB code
6okq
Structure name
crystal structure of the sf12 fab
Structure deposition date
2019-04-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
369
Residue number B
96
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 369 of Immunoglobulin gamma-1 heavy chain
Cysteine 96 of Immunoglobulin gamma-1 heavy chain
8dao G 140 G 196
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 146 and 202 (140 and 196 respectively in this structure).
Details
Redox score ?
79
PDB code
8dao
Structure name
crystal structure of sars-cov-2 spike stem fusion peptide in complex with neutralizing antibody cov44-79
Structure deposition date
2022-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
146
Residue number B
202
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 146 of Immunoglobulin gamma-1 heavy chain
Cysteine 202 of Immunoglobulin gamma-1 heavy chain
5xmh A 367 A 425
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 369 and 427 (367 and 425 respectively in this structure).
Details
Redox score ?
78
PDB code
5xmh
Structure name
crystal structure of an igm rheumatoid factor yes8c in complex with igg1 fc
Structure deposition date
2017-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
369
Residue number B
427
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 369 of Immunoglobulin gamma-1 heavy chain
Cysteine 427 of Immunoglobulin gamma-1 heavy chain
6mu3 M 22 M 92
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 22 and 96 (22 and 92 respectively in this structure).
Details
Redox score ?
73
PDB code
6mu3
Structure name
anti-hiv-1 fab 2g12 + man7 re-refinement
Structure deposition date
2018-10-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
50
Peptide accession
P0DOX5
Residue number A
22
Residue number B
96
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 22 of Immunoglobulin gamma-1 heavy chain
Cysteine 96 of Immunoglobulin gamma-1 heavy chain
6v8z C 22 C 104
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 22 and 202 (22 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6v8z
Structure name
vrc03 and 10-1074 bound bg505 f14 hiv-1 sosip envelope trimer structure
Structure deposition date
2019-12-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
nan
Peptide accession
P0DOX5
Residue number A
22
Residue number B
202
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 22 of Immunoglobulin gamma-1 heavy chain
Cysteine 202 of Immunoglobulin gamma-1 heavy chain
Uncertain whether structure cysteine 104 has been assigned to correct residue.
6v8z O 92 O 104
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 96 and 202 (92 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6v8z
Structure name
vrc03 and 10-1074 bound bg505 f14 hiv-1 sosip envelope trimer structure
Structure deposition date
2019-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
nan
Peptide accession
P0DOX5
Residue number A
96
Residue number B
202
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 96 of Immunoglobulin gamma-1 heavy chain
Cysteine 202 of Immunoglobulin gamma-1 heavy chain
Uncertain whether structure cysteine 104 has been assigned to correct residue.
6v8z O 98 O 100
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 22 and 100 (98 and 100 respectively in this structure).
Details
Redox score ?
nan
PDB code
6v8z
Structure name
vrc03 and 10-1074 bound bg505 f14 hiv-1 sosip envelope trimer structure
Structure deposition date
2019-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
22
Residue number B
100
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 22 of Immunoglobulin gamma-1 heavy chain
Cysteine 100 of Immunoglobulin gamma-1 heavy chain
Uncertain whether structure cysteine 98 has been assigned to correct residue.
Cysteine 100 in protein B could not be asigned to a Uniprot residue.
8dv1 D 344 D 361
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 344 and 361.
Details
Redox score ?
nan
PDB code
8dv1
Structure name
sars-cov-2 wuhan-hu-1-spike-rbd bound to linker variant of affinity matured ace2 mimetic cvd432
Structure deposition date
2022-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
344
Residue number B
361
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 344 of Immunoglobulin gamma-1 heavy chain
Cysteine 361 of Immunoglobulin gamma-1 heavy chain
Cysteine 344 in protein A could not be asigned to a Uniprot residue.
Cysteine 361 in protein B could not be asigned to a Uniprot residue.
6bkb H 100 H 100
A redox-regulated disulphide may form within Immunoglobulin gamma-1 heavy chain between cysteines 100 and 100.
Details
Redox score ?
nan
PDB code
6bkb
Structure name
structure of hepatitis c virus envelope glycoprotein e2 core from genotype 6a bound to broadly neutralizing antibody ar3a
Structure deposition date
2017-11-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX5
Residue number A
100
Residue number B
100
Peptide name
Immunoglobulin gamma-1 heavy chain
Ligandability
Cysteine 100 in protein A could not be asigned to a Uniprot residue.
Cysteine 100 in protein B could not be asigned to a Uniprot residue.
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