ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoglobulin kappa light chain

Intramolecular
Cysteine 134 and cysteine 194
Cysteine 23 and cysteine 88
A redox-regulated disulphide may form within Immunoglobulin kappa light chain between cysteines 134 and 194.

Details

Redox score ?
71
PDB code
6n32
Structure name
anti-hiv-1 fab 2g12 re-refinement
Structure deposition date
2018-11-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
44
Peptide accession
P0DOX7
Residue number A
134
Residue number B
194
Peptide name
Immunoglobulin kappa light chain

Ligandability

Cysteine 134 of Immunoglobulin kappa light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Immunoglobulin kappa light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin kappa light chain between cysteines 23 and 88.

Details

Redox score ?
70
PDB code
5vig
Structure name
crystal structure of anti-zika antibody z006 bound to zika virus envelope protein diii
Structure deposition date
2017-04-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
P0DOX7
Residue number A
23
Residue number B
88
Peptide name
Immunoglobulin kappa light chain

Ligandability

Cysteine 23 of Immunoglobulin kappa light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Immunoglobulin kappa light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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