ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoglobulin lambda-1 light chain

Intermolecular
Cysteine 215 and cysteine 215
Intramolecular
Cysteine 22 and cysteine 90
Cysteine 138 and cysteine 197
A redox-regulated disulphide may form between two units of Immunoglobulin lambda-1 light chain at cysteines 215 and 215.

Details

Redox score ?
85
PDB code
1mce
Structure name
principles and pitfalls in designing site directed peptide ligands
Structure deposition date
1993-02-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin lambda-1 light chain
Peptide B name
Immunoglobulin lambda-1 light chain
Peptide A accession
P0DOX8
Peptide B accession
P0DOX8
Peptide A residue number
215
Peptide B residue number
215

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin lambda-1 light chain between cysteines 22 and 90.

Details

Redox score ?
80
PDB code
1mcf
Structure name
principles and pitfalls in designing site directed peptide ligands
Structure deposition date
1993-02-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX8
Residue number A
22
Residue number B
90
Peptide name
Immunoglobulin lambda-1 light chain

Ligandability

Cysteine 22 of Immunoglobulin lambda-1 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Immunoglobulin lambda-1 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin lambda-1 light chain between cysteines 138 and 197.

Details

Redox score ?
78
PDB code
1mcf
Structure name
principles and pitfalls in designing site directed peptide ligands
Structure deposition date
1993-02-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOX8
Residue number A
138
Residue number B
197
Peptide name
Immunoglobulin lambda-1 light chain

Ligandability

Cysteine 138 of Immunoglobulin lambda-1 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Immunoglobulin lambda-1 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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