ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoglobulin lambda constant 2

Intramolecular
Cysteine 28 and cysteine 28
Cysteine 28 and cysteine 87
A redox-regulated disulphide may form within Immunoglobulin lambda constant 2 between cysteines 28 and 28 (22 and 89 respectively in this structure).

Details

Redox score ?
81
PDB code
6umx
Structure name
structural basis for specific inhibition of extracellular activation of pro/latent myostatin by srk-015
Structure deposition date
2019-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOY2
Residue number A
28
Residue number B
28
Peptide name
Immunoglobulin lambda constant 2

Ligandability

Cysteine 28 of Immunoglobulin lambda constant 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 28 of Immunoglobulin lambda constant 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 89 has been assigned to correct residue.
A redox-regulated disulphide may form within Immunoglobulin lambda constant 2 between cysteines 28 and 87 (138 and 197 respectively in this structure).

Details

Redox score ?
78
PDB code
4eow
Structure name
crystal structure of a disease-associated anti-human gm-csf autoantibody mb007
Structure deposition date
2012-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P0DOY2
Residue number A
28
Residue number B
87
Peptide name
Immunoglobulin lambda constant 2

Ligandability

Cysteine 28 of Immunoglobulin lambda constant 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Immunoglobulin lambda constant 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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