Immunoglobulin lambda constant 3

Intermolecular

Cysteine 105 and cysteine 245 of Ig-like domain-containing protein

Intramolecular

A redox-regulated disulphide may form between cysteine 105 of Immunoglobulin lambda constant 3 and cysteine 245 of Ig-like domain-containing protein (211 and 216 respectively in this structure).

Details

Redox score ?

PDB code

4o5l

Structure name

crystal structure of broadly neutralizing antibody f045-092

Structure deposition date

2013-12-19

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Immunoglobulin lambda constant 3

Peptide B name

Ig-like domain-containing protein

Peptide A accession

P0DOY3

Peptide B accession

A8K008

Peptide A residue number

105

Peptide B residue number

245

Ligandability

Cysteine 105 of Immunoglobulin lambda constant 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin lambda constant 3 between cysteines 28 and 87 (135 and 194 respectively in this structure).

Details

Redox score ?

PDB code

4r2g

Structure name

crystal structure of pgt124 fab bound to hiv-1 jrcsf gp120 core and to cd4

Structure deposition date

2014-08-11

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P0DOY3

Residue number A

Residue number B

Peptide name

Immunoglobulin lambda constant 3

Ligandability

Cysteine 28 of Immunoglobulin lambda constant 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Immunoglobulin lambda constant 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin lambda constant 3 between cysteines 28 and 88 (23 and 88 respectively in this structure).