Interleukin-8
Intramolecular
Cysteine 34 and cysteine 61
Cysteine 36 and cysteine 77
Cysteine 36 and cysteine 38
Cysteine 61 and cysteine 38
Cysteine 36 and cysteine 61
Cysteine 5 and cysteine 61
Cysteine 34 and cysteine 33
Cysteine 34 and cysteine 36
Cysteine 34 and cysteine 77
Cysteine 61 and cysteine 77
Cysteine 5 and cysteine 33
1qe6 D 7 D 34
A redox-regulated disulphide may form within Interleukin-8 between cysteines 34 and 61 (7 and 34 respectively in this structure).
Details
Redox score ?
88
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
34
Residue number B
61
Peptide name
Interleukin-8
Ligandability
Cysteine 34 of Interleukin-8
Cysteine 61 of Interleukin-8
1qe6 A 9 A 50
A redox-regulated disulphide may form within Interleukin-8 between cysteines 36 and 77 (9 and 50 respectively in this structure).
Details
Redox score ?
86
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
36
Residue number B
77
Peptide name
Interleukin-8
Ligandability
Cysteine 36 of Interleukin-8
Cysteine 77 of Interleukin-8
1icw A 9 A 38
A redox-regulated disulphide may form within Interleukin-8 between cysteines 36 and 38 (9 and 38 respectively in this structure).
Details
Redox score ?
83
PDB code
1icw
Structure name
interleukin-8, mutant with glu 38 replaced by cys and cys 50 replaced by ala
Structure deposition date
1996-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
36
Residue number B
38
Peptide name
Interleukin-8
Ligandability
Cysteine 36 of Interleukin-8
Cysteine 38 of Interleukin-8
Cysteine 38 in protein B could not be asigned to a Uniprot residue.
1icw A 34 A 38
A redox-regulated disulphide may form within Interleukin-8 between cysteines 61 and 38 (34 and 38 respectively in this structure).
Details
Redox score ?
71
PDB code
1icw
Structure name
interleukin-8, mutant with glu 38 replaced by cys and cys 50 replaced by ala
Structure deposition date
1996-09-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
61
Residue number B
38
Peptide name
Interleukin-8
Ligandability
Cysteine 61 of Interleukin-8
Cysteine 38 of Interleukin-8
Cysteine 38 in protein B could not be asigned to a Uniprot residue.
1qe6 B 9 B 34
A redox-regulated disulphide may form within Interleukin-8 between cysteines 36 and 61 (9 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
36
Residue number B
61
Peptide name
Interleukin-8
Ligandability
Cysteine 36 of Interleukin-8
Cysteine 61 of Interleukin-8
1qe6 A 5 A 34
A redox-regulated disulphide may form within Interleukin-8 between cysteines 5 and 61 (5 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
5
Residue number B
61
Peptide name
Interleukin-8
Ligandability
Cysteine 5 of Interleukin-8
Cysteine 61 of Interleukin-8
Cysteine 5 in protein A could not be asigned to a Uniprot residue.
1qe6 B 7 B 33
A redox-regulated disulphide may form within Interleukin-8 between cysteines 34 and 33 (7 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
34
Residue number B
33
Peptide name
Interleukin-8
Ligandability
Cysteine 34 of Interleukin-8
Cysteine 33 of Interleukin-8
Cysteine 33 in protein B could not be asigned to a Uniprot residue.
6wzm F 7 F 9
A redox-regulated disulphide may form within Interleukin-8 between cysteines 34 and 36 (7 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6wzm
Structure name
ly3041658 fab bound to cxcl8
Structure deposition date
2020-05-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
34
Residue number B
36
Peptide name
Interleukin-8
Ligandability
Cysteine 34 of Interleukin-8
Cysteine 36 of Interleukin-8
6n2u A 5 A 48
A redox-regulated disulphide may form within Interleukin-8 between cysteines 34 and 77 (5 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6n2u
Structure name
il-8 structure from bacterial expression source
Structure deposition date
2018-11-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
34
Residue number B
77
Peptide name
Interleukin-8
Ligandability
Cysteine 34 of Interleukin-8
Cysteine 77 of Interleukin-8
6wzm F 34 F 50
A redox-regulated disulphide may form within Interleukin-8 between cysteines 61 and 77 (34 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6wzm
Structure name
ly3041658 fab bound to cxcl8
Structure deposition date
2020-05-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
61
Residue number B
77
Peptide name
Interleukin-8
Ligandability
Cysteine 61 of Interleukin-8
Cysteine 77 of Interleukin-8
1qe6 B 5 B 33
A redox-regulated disulphide may form within Interleukin-8 between cysteines 5 and 33.
Details
Redox score ?
nan
PDB code
1qe6
Structure name
interleukin-8 with an added disulfide between residues 5 and 33 (l5c/h33c)
Structure deposition date
1999-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10145
Residue number A
5
Residue number B
33
Peptide name
Interleukin-8
Ligandability
Cysteine 5 of Interleukin-8
Cysteine 33 of Interleukin-8
Cysteine 5 in protein A could not be asigned to a Uniprot residue.
Cysteine 33 in protein B could not be asigned to a Uniprot residue.
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