Lysosomal alpha-glucosidase
Intramolecular
Cysteine 103 and cysteine 127
Cysteine 82 and cysteine 109
Cysteine 92 and cysteine 108
Cysteine 533 and cysteine 558
Cysteine 647 and cysteine 658
Cysteine 92 and cysteine 127
Cysteine 108 and cysteine 127
Cysteine 103 and cysteine 108
Cysteine 92 and cysteine 103
Cysteine 103 and cysteine 109
More...Cysteine 108 and cysteine 109
Cysteine 82 and cysteine 103
Cysteine 82 and cysteine 108
Cysteine 109 and cysteine 127
Cysteine 92 and cysteine 109
Cysteine 82 and cysteine 127
5nn5 A 103 A 127
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 103 and 127.
Details
Redox score ?
85
PDB code
5nn5
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with 1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
103
Residue number B
127
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 103 of Lysosomal alpha-glucosidase
Cysteine 127 of Lysosomal alpha-glucosidase
5nn5 A 82 A 109
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 82 and 109.
Details
Redox score ?
84
PDB code
5nn5
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with 1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
82
Residue number B
109
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 82 of Lysosomal alpha-glucosidase
Cysteine 109 of Lysosomal alpha-glucosidase
5nn6 A 92 A 108
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 92 and 108.
Details
Redox score ?
84
PDB code
5nn6
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with n-hydroxyethyl-1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
92
Residue number B
108
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 92 of Lysosomal alpha-glucosidase
Cysteine 108 of Lysosomal alpha-glucosidase
5nn8 A 533 A 558
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 533 and 558.
Details
Redox score ?
84
PDB code
5nn8
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with acarbose
Structure deposition date
2017-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
533
Residue number B
558
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 533 of Lysosomal alpha-glucosidase
Cysteine 558 of Lysosomal alpha-glucosidase
5nn8 A 647 A 658
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 647 and 658.
Details
Redox score ?
76
PDB code
5nn8
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with acarbose
Structure deposition date
2017-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
647
Residue number B
658
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 647 of Lysosomal alpha-glucosidase
Cysteine 658 of Lysosomal alpha-glucosidase
5kzw A 92 A 127
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 92 and 127.
Details
Redox score ?
70
PDB code
5kzw
Structure name
crystal structure of human gaa
Structure deposition date
2016-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
92
Residue number B
127
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 92 of Lysosomal alpha-glucosidase
Cysteine 127 of Lysosomal alpha-glucosidase
5nn6 A 108 A 127
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 108 and 127.
Details
Redox score ?
68
PDB code
5nn6
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with n-hydroxyethyl-1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
108
Residue number B
127
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 108 of Lysosomal alpha-glucosidase
Cysteine 127 of Lysosomal alpha-glucosidase
5nn4 A 103 A 108
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 103 and 108.
Details
Redox score ?
67
PDB code
5nn4
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with n-acetyl-cysteine
Structure deposition date
2017-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
103
Residue number B
108
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 103 of Lysosomal alpha-glucosidase
Cysteine 108 of Lysosomal alpha-glucosidase
5nn8 A 92 A 103
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 92 and 103.
Details
Redox score ?
67
PDB code
5nn8
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with acarbose
Structure deposition date
2017-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
92
Residue number B
103
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 92 of Lysosomal alpha-glucosidase
Cysteine 103 of Lysosomal alpha-glucosidase
5nn5 A 103 A 109
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 103 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5nn5
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with 1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
103
Residue number B
109
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 103 of Lysosomal alpha-glucosidase
Cysteine 109 of Lysosomal alpha-glucosidase
5nn4 A 108 A 109
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 108 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5nn4
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with n-acetyl-cysteine
Structure deposition date
2017-04-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
108
Residue number B
109
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 108 of Lysosomal alpha-glucosidase
Cysteine 109 of Lysosomal alpha-glucosidase
5kzx A 82 A 103
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 82 and 103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5kzx
Structure name
crystal structure of human gaa
Structure deposition date
2016-07-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
82
Residue number B
103
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 82 of Lysosomal alpha-glucosidase
Cysteine 103 of Lysosomal alpha-glucosidase
5kzx A 82 A 108
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 82 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
5kzx
Structure name
crystal structure of human gaa
Structure deposition date
2016-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
82
Residue number B
108
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 82 of Lysosomal alpha-glucosidase
Cysteine 108 of Lysosomal alpha-glucosidase
5nn5 A 109 A 127
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 109 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5nn5
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with 1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
109
Residue number B
127
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 109 of Lysosomal alpha-glucosidase
Cysteine 127 of Lysosomal alpha-glucosidase
5nn6 A 92 A 109
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 92 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5nn6
Structure name
crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with n-hydroxyethyl-1-deoxynojirimycin
Structure deposition date
2017-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
92
Residue number B
109
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 92 of Lysosomal alpha-glucosidase
Cysteine 109 of Lysosomal alpha-glucosidase
5kzx A 82 A 127
A redox-regulated disulphide may form within Lysosomal alpha-glucosidase between cysteines 82 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5kzx
Structure name
crystal structure of human gaa
Structure deposition date
2016-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10253
Residue number A
82
Residue number B
127
Peptide name
Lysosomal alpha-glucosidase
Ligandability
Cysteine 82 of Lysosomal alpha-glucosidase
Cysteine 127 of Lysosomal alpha-glucosidase
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