Retinoic acid receptor alpha
Intramolecular
Cysteine 124 and cysteine 130
Cysteine 88 and cysteine 108
Cysteine 124 and cysteine 140
Cysteine 124 and cysteine 143
Cysteine 105 and cysteine 108
Cysteine 91 and cysteine 108
Cysteine 130 and cysteine 143
Cysteine 130 and cysteine 140
Cysteine 140 and cysteine 143
Cysteine 108 and cysteine 148
More...Cysteine 88 and cysteine 91
Cysteine 91 and cysteine 105
Cysteine 88 and cysteine 148
Cysteine 88 and cysteine 105
Cysteine 105 and cysteine 148
Cysteine 91 and cysteine 148
Cysteine 235 and cysteine 265
Cysteine 333 and cysteine 336
Cysteine 265 and cysteine 333
1dsz A 1171 A 1177
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 124 and 130 (1171 and 1177 respectively in this structure).
Details
Redox score ?
91
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
0
Peptide accession
P10276
Residue number A
124
Residue number B
130
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 124 of Retinoic acid receptor alpha
Cysteine 130 of Retinoic acid receptor alpha
1dsz A 1135 A 1155
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 88 and 108 (1135 and 1155 respectively in this structure).
Details
Redox score ?
87
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
4
% buried
nan
Peptide accession
P10276
Residue number A
88
Residue number B
108
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 88 of Retinoic acid receptor alpha
Cysteine 108 of Retinoic acid receptor alpha
1dsz A 1171 A 1187
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 124 and 140 (1171 and 1187 respectively in this structure).
Details
Redox score ?
87
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
10
Peptide accession
P10276
Residue number A
124
Residue number B
140
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 124 of Retinoic acid receptor alpha
Cysteine 140 of Retinoic acid receptor alpha
1dsz A 1171 A 1190
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 124 and 143 (1171 and 1190 respectively in this structure).
Details
Redox score ?
85
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
3
Peptide accession
P10276
Residue number A
124
Residue number B
143
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 124 of Retinoic acid receptor alpha
Cysteine 143 of Retinoic acid receptor alpha
1dsz A 1152 A 1155
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 105 and 108 (1152 and 1155 respectively in this structure).
Details
Redox score ?
83
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
81
Peptide accession
P10276
Residue number A
105
Residue number B
108
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 105 of Retinoic acid receptor alpha
Cysteine 108 of Retinoic acid receptor alpha
1dsz A 1138 A 1155
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 91 and 108 (1138 and 1155 respectively in this structure).
Details
Redox score ?
83
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
4
% buried
71
Peptide accession
P10276
Residue number A
91
Residue number B
108
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 91 of Retinoic acid receptor alpha
Cysteine 108 of Retinoic acid receptor alpha
1dsz A 1177 A 1190
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 130 and 143 (1177 and 1190 respectively in this structure).
Details
Redox score ?
80
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
3
Peptide accession
P10276
Residue number A
130
Residue number B
143
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 130 of Retinoic acid receptor alpha
Cysteine 143 of Retinoic acid receptor alpha
1dsz A 1177 A 1187
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 130 and 140 (1177 and 1187 respectively in this structure).
Details
Redox score ?
77
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
10
Peptide accession
P10276
Residue number A
130
Residue number B
140
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 130 of Retinoic acid receptor alpha
Cysteine 140 of Retinoic acid receptor alpha
1dsz A 1187 A 1190
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 140 and 143 (1187 and 1190 respectively in this structure).
Details
Redox score ?
77
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
14
Peptide accession
P10276
Residue number A
140
Residue number B
143
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 140 of Retinoic acid receptor alpha
Cysteine 143 of Retinoic acid receptor alpha
1dsz A 1155 A 1195
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 108 and 148 (1155 and 1195 respectively in this structure).
Details
Redox score ?
74
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
4
% buried
94
Peptide accession
P10276
Residue number A
108
Residue number B
148
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 108 of Retinoic acid receptor alpha
Cysteine 148 of Retinoic acid receptor alpha
1dsz A 1135 A 1138
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 88 and 91 (1135 and 1138 respectively in this structure).
Details
Redox score ?
68
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
13
% buried
nan
Peptide accession
P10276
Residue number A
88
Residue number B
91
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 88 of Retinoic acid receptor alpha
Cysteine 91 of Retinoic acid receptor alpha
1dsz A 1138 A 1152
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 91 and 105 (1138 and 1152 respectively in this structure).
Details
Redox score ?
65
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
13
% buried
65
Peptide accession
P10276
Residue number A
91
Residue number B
105
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 91 of Retinoic acid receptor alpha
Cysteine 105 of Retinoic acid receptor alpha
1dsz A 1135 A 1195
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 88 and 148 (1135 and 1195 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
13
% buried
nan
Peptide accession
P10276
Residue number A
88
Residue number B
148
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 88 of Retinoic acid receptor alpha
Cysteine 148 of Retinoic acid receptor alpha
1dsz A 1135 A 1152
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 88 and 105 (1135 and 1152 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
22
% buried
nan
Peptide accession
P10276
Residue number A
88
Residue number B
105
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 88 of Retinoic acid receptor alpha
Cysteine 105 of Retinoic acid receptor alpha
1dsz A 1152 A 1195
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 105 and 148 (1152 and 1195 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
13
% buried
88
Peptide accession
P10276
Residue number A
105
Residue number B
148
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 105 of Retinoic acid receptor alpha
Cysteine 148 of Retinoic acid receptor alpha
1dsz A 1138 A 1195
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 91 and 148 (1138 and 1195 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1dsz
Structure name
structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1
Structure deposition date
2000-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
13
% buried
78
Peptide accession
P10276
Residue number A
91
Residue number B
148
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 91 of Retinoic acid receptor alpha
Cysteine 148 of Retinoic acid receptor alpha
1dkf B 235 B 265
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 235 and 265. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
1dkf
Structure name
crystal structure of a heterodimeric complex of rar and rxr ligand- binding domains
Structure deposition date
1999-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
100
Peptide accession
P10276
Residue number A
235
Residue number B
265
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 235 of Retinoic acid receptor alpha
Cysteine 265 of Retinoic acid receptor alpha
7apo A 333 A 336
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 333 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7apo
Structure name
crystal structure of raralpha ligand binding domain in complex with a fragment of the tif2 coactivator
Structure deposition date
2020-10-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
100
Peptide accession
P10276
Residue number A
333
Residue number B
336
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 333 of Retinoic acid receptor alpha
Cysteine 336 of Retinoic acid receptor alpha
4dqm C 265 C 333
A redox-regulated disulphide may form within Retinoic acid receptor alpha between cysteines 265 and 333. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
4dqm
Structure name
revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity
Structure deposition date
2012-02-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
P10276
Residue number A
265
Residue number B
333
Peptide name
Retinoic acid receptor alpha
Ligandability
Cysteine 265 of Retinoic acid receptor alpha
Cysteine 333 of Retinoic acid receptor alpha
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