ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase F

Intramolecular
Cysteine 54 and cysteine 107
Cysteine 156 and cysteine 207
Cysteine 1460 and cysteine 1548
Cysteine 1548 and cysteine 1557
Cysteine 1749 and cysteine 1839
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase F between cysteines 54 and 107.

Details

Redox score ?
81
PDB code
3pxh
Structure name
tandem ig domains of tyrosine phosphatase lar
Structure deposition date
2010-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2A8L5
Residue number A
54
Residue number B
107
Peptide name
Receptor-type tyrosine-protein phosphatase F

Ligandability

Cysteine 54 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase F between cysteines 156 and 207.

Details

Redox score ?
81
PDB code
3pxh
Structure name
tandem ig domains of tyrosine phosphatase lar
Structure deposition date
2010-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2A8L5
Residue number A
156
Residue number B
207
Peptide name
Receptor-type tyrosine-protein phosphatase F

Ligandability

Cysteine 156 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase F between cysteines 1460 and 1548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6kr4
Structure name
crystal structure of the liprin-alpha3_sam123/lar_d1d2 complex
Structure deposition date
2019-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
99
Peptide accession
P10586
Residue number A
1460
Residue number B
1548
Peptide name
Receptor-type tyrosine-protein phosphatase F

Ligandability

Cysteine 1460 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1548 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase F between cysteines 1548 and 1557 (1522 and 1531 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1lar
Structure name
crystal structure of the tandem phosphatase domains of rptp lar
Structure deposition date
1999-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
8
% buried
100
Peptide accession
P10586
Residue number A
1548
Residue number B
1557
Peptide name
Receptor-type tyrosine-protein phosphatase F

Ligandability

Cysteine 1548 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1557 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase F between cysteines 1749 and 1839. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6kr4
Structure name
crystal structure of the liprin-alpha3_sam123/lar_d1d2 complex
Structure deposition date
2019-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
98
Peptide accession
P10586
Residue number A
1749
Residue number B
1839
Peptide name
Receptor-type tyrosine-protein phosphatase F

Ligandability

Cysteine 1749 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1839 of Receptor-type tyrosine-protein phosphatase F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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