Thioredoxin
Intermolecular
Cysteine 32 and cysteine 61 of Nuclear factor NF-kappa-B p105 subunit L
Cysteine 32 and cysteine 65 of DNA-(apurinic or apyrimidinic site) endonuclease L
Cysteine 647 of Thioredoxin reductase 1, cytoplasmic and cysteine 32 L
Cysteine 62 and cysteine 62
Cysteine 73 and cysteine 62 L
Cysteine 73 and cysteine 73 L
Cysteine 247 of Thioredoxin-interacting protein and cysteine 32 L
Cysteine 32 and cysteine 73 L
Cysteine 73 and cysteine 69 L
Cysteine 32 and cysteine 62 L
More...Cysteine 35 and cysteine 62 L
Cysteine 247 of Thioredoxin-interacting protein and cysteine 73 L
Intramolecular
Cysteine 32 and cysteine 69 L
Cysteine 32 and cysteine 35 L
Cysteine 35 and cysteine 69 L
Cysteine 35 and cysteine 73 L
Cysteine 62 and cysteine 69
1mdi A 32 B 7
A redox-regulated disulphide may form between cysteine 32 of Thioredoxin and cysteine 61 of Nuclear factor NF-kappa-B p105 subunit (32 and 7 respectively in this structure).
Details
Redox score ?
88
PDB code
1mdi
Structure name
high resolution solution nmr structure of mixed disulfide intermediate between mutant human thioredoxin and a 13 residue peptide comprising its target site in human nfkb
Structure deposition date
1995-02-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Nuclear factor NF-kappa-B p105 subunit
Peptide A accession
P10599
Peptide B accession
P19838
Peptide A residue number
32
Peptide B residue number
61
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 61 of Nuclear factor NF-kappa-B p105 subunit
1cqh A 32 B 65
A redox-regulated disulphide may form between cysteine 32 of Thioredoxin and cysteine 65 of DNA-(apurinic or apyrimidinic site) endonuclease.
Details
Redox score ?
86
PDB code
1cqh
Structure name
high resolution solution nmr structure of mixed disulfide intermediate between human thioredoxin (c35a, c62a, c69a, c73a) mutant and a 13 residue peptide comprising its target site in human ref-1 (residues 59-71 of the p50 subunit of nfkb), nmr, minimized average structure
Structure deposition date
1996-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
DNA-(apurinic or apyrimidinic site) endonuclease
Peptide A accession
P10599
Peptide B accession
P27695
Peptide A residue number
32
Peptide B residue number
65
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 65 of DNA-(apurinic or apyrimidinic site) endonuclease
3qfa A 498 D 32
A redox-regulated disulphide may form between cysteine 647 of Thioredoxin reductase 1, cytoplasmic and cysteine 32 of Thioredoxin (498 and 32 respectively in this structure).
Details
Redox score ?
84
PDB code
3qfa
Structure name
crystal structure of the human thioredoxin reductase-thioredoxin complex
Structure deposition date
2011-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin reductase 1, cytoplasmic
Peptide B name
Thioredoxin
Peptide A accession
Q16881
Peptide B accession
P10599
Peptide A residue number
647
Peptide B residue number
32
Ligandability
Cysteine 647 of Thioredoxin reductase 1, cytoplasmic
Cysteine 32 of Thioredoxin
3m9k A 62 B 62
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 62 and 62.
Details
Redox score ?
84
PDB code
3m9k
Structure name
crystal structure of human thioredoxin c69/73s double-mutant, oxidized form
Structure deposition date
2010-03-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
62
Peptide B residue number
62
Ligandability
4pol B 73 D 62
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 73 and 62.
Details
Redox score ?
82
PDB code
4pol
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
73
Peptide B residue number
62
Ligandability
Cysteine 73 of Thioredoxin
Cysteine 62 of Thioredoxin
2ifq A 73 B 73
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 73 and 73.
Details
Redox score ?
78
PDB code
2ifq
Structure name
crystal structure of s-nitroso thioredoxin
Structure deposition date
2006-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
73
Peptide B residue number
73
Ligandability
4ll1 A 247 B 32
A redox-regulated disulphide may form between cysteine 247 of Thioredoxin-interacting protein and cysteine 32 of Thioredoxin.
Details
Redox score ?
78
PDB code
4ll1
Structure name
the structure of the trx and txnip complex
Structure deposition date
2013-07-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
82
Peptide A name
Thioredoxin-interacting protein
Peptide B name
Thioredoxin
Peptide A accession
Q9H3M7
Peptide B accession
P10599
Peptide A residue number
247
Peptide B residue number
32
Ligandability
Cysteine 247 of Thioredoxin-interacting protein
Cysteine 32 of Thioredoxin
4pok C 32 D 73
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 32 and 73.
Details
Redox score ?
63
PDB code
4pok
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
32
Peptide B residue number
73
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 73 of Thioredoxin
4pok C 73 D 69
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 73 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4pok
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
73
Peptide B residue number
69
Ligandability
Cysteine 73 of Thioredoxin
Cysteine 69 of Thioredoxin
4pok B 32 D 62
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 32 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4pok
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
32
Peptide B residue number
62
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 62 of Thioredoxin
4pok B 35 D 62
A redox-regulated disulphide may form between two units of Thioredoxin at cysteines 35 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4pok
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Thioredoxin
Peptide A accession
P10599
Peptide B accession
P10599
Peptide A residue number
35
Peptide B residue number
62
Ligandability
Cysteine 35 of Thioredoxin
Cysteine 62 of Thioredoxin
4ll4 C 247 D 73
A redox-regulated disulphide may form between cysteine 247 of Thioredoxin-interacting protein and cysteine 73 of Thioredoxin. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4ll4
Structure name
the structure of the trx and txnip complex
Structure deposition date
2013-07-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
10
% buried
nan
Peptide A name
Thioredoxin-interacting protein
Peptide B name
Thioredoxin
Peptide A accession
Q9H3M7
Peptide B accession
P10599
Peptide A residue number
247
Peptide B residue number
73
Ligandability
Cysteine 247 of Thioredoxin-interacting protein
Cysteine 73 of Thioredoxin
4pol D 32 D 69
A redox-regulated disulphide may form within Thioredoxin between cysteines 32 and 69.
Details
Redox score ?
85
PDB code
4pol
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10599
Residue number A
32
Residue number B
69
Peptide name
Thioredoxin
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 69 of Thioredoxin
2ifq B 32 B 35
A redox-regulated disulphide may form within Thioredoxin between cysteines 32 and 35.
Details
Redox score ?
77
PDB code
2ifq
Structure name
crystal structure of s-nitroso thioredoxin
Structure deposition date
2006-09-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
40
Peptide accession
P10599
Residue number A
32
Residue number B
35
Peptide name
Thioredoxin
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 35 of Thioredoxin
4pom D 35 D 69
A redox-regulated disulphide may form within Thioredoxin between cysteines 35 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4pom
Structure name
crystal structures of thioredoxin with mesna at 1
Structure deposition date
2014-02-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10599
Residue number A
35
Residue number B
69
Peptide name
Thioredoxin
Ligandability
Cysteine 35 of Thioredoxin
Cysteine 69 of Thioredoxin
4pol A 35 A 73
A redox-regulated disulphide may form within Thioredoxin between cysteines 35 and 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4pol
Structure name
crystal structures of thioredoxin with mesna at 2
Structure deposition date
2014-02-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10599
Residue number A
35
Residue number B
73
Peptide name
Thioredoxin
Ligandability
Cysteine 35 of Thioredoxin
Cysteine 73 of Thioredoxin
1auc A 62 A 69
A redox-regulated disulphide may form within Thioredoxin between cysteines 62 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1auc
Structure name
human thioredoxin (oxidized with diamide)
Structure deposition date
1997-08-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
11
% buried
31
Peptide accession
P10599
Residue number A
62
Residue number B
69
Peptide name
Thioredoxin
Ligandability
Cysteine 62 of Thioredoxin
Cysteine 69 of Thioredoxin
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