Lysosomal protective protein
Intramolecular
Cysteine 241 and cysteine 246
Cysteine 240 and cysteine 256
Cysteine 281 and cysteine 331
Cysteine 88 and cysteine 362
Cysteine 240 and cysteine 241
Cysteine 241 and cysteine 256
Cysteine 240 and cysteine 246
Cysteine 246 and cysteine 256
4ci9 A 213 A 218
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 241 and 246 (213 and 218 respectively in this structure).
Details
Redox score ?
87
PDB code
4ci9
Structure name
crystal structure of cathepsin a, apo-structure
Structure deposition date
2013-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
241
Residue number B
246
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 241 of Lysosomal protective protein
Cysteine 246 of Lysosomal protective protein
4az0 A 212 A 228
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 240 and 256 (212 and 228 respectively in this structure).
Details
Redox score ?
86
PDB code
4az0
Structure name
crystal structure of cathepsin a, complexed with 8a
Structure deposition date
2012-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
240
Residue number B
256
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 240 of Lysosomal protective protein
Cysteine 256 of Lysosomal protective protein
1ivy A 253 A 303
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 281 and 331 (253 and 303 respectively in this structure).
Details
Redox score ?
84
PDB code
1ivy
Structure name
physiological dimer hpp precursor
Structure deposition date
1996-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
281
Residue number B
331
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 281 of Lysosomal protective protein
Cysteine 331 of Lysosomal protective protein
4cia A 60 A 334
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 88 and 362 (60 and 334 respectively in this structure).
Details
Redox score ?
78
PDB code
4cia
Structure name
crystal structure of cathepsin a, complexed with compound 1
Structure deposition date
2013-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
88
Residue number B
362
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 88 of Lysosomal protective protein
Cysteine 362 of Lysosomal protective protein
4az0 A 212 A 213
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 240 and 241 (212 and 213 respectively in this structure).
Details
Redox score ?
63
PDB code
4az0
Structure name
crystal structure of cathepsin a, complexed with 8a
Structure deposition date
2012-06-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
240
Residue number B
241
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 240 of Lysosomal protective protein
Cysteine 241 of Lysosomal protective protein
4cib A 213 A 228
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 241 and 256 (213 and 228 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4cib
Structure name
crystal structure of cathepsin a, complexed with compound 2
Structure deposition date
2013-12-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
241
Residue number B
256
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 241 of Lysosomal protective protein
Cysteine 256 of Lysosomal protective protein
4mws A 212 A 218
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 240 and 246 (212 and 218 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
4mws
Structure name
crystal structure of human ppca (trigonal crystal form 1)
Structure deposition date
2013-09-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
240
Residue number B
246
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 240 of Lysosomal protective protein
Cysteine 246 of Lysosomal protective protein
4az0 A 218 A 228
A redox-regulated disulphide may form within Lysosomal protective protein between cysteines 246 and 256 (218 and 228 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4az0
Structure name
crystal structure of cathepsin a, complexed with 8a
Structure deposition date
2012-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10619
Residue number A
246
Residue number B
256
Peptide name
Lysosomal protective protein
Ligandability
Cysteine 246 of Lysosomal protective protein
Cysteine 256 of Lysosomal protective protein
If this tool was useful for finding a disulphide, please cite: