Cytochrome P450 2D6

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Cytochrome P450 2D6 at cysteines 57 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4xry

Structure name

human cytochrome p450 2d6 bace1 inhibitor 5 complex

Structure deposition date

2015-01-21

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Cytochrome P450 2D6

Peptide B name

Cytochrome P450 2D6

Peptide A accession

P10635

Peptide B accession

P10635

Peptide A residue number

Peptide B residue number

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome P450 2D6 between cysteines 159 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?